Arbeitspapier
Estimation of toxicokinetic population parameters in a four-stage hierarchical model
A basic part in the risk assessment of potential carcinogens is the determination of toxicokinetic parameters. The partition of the xenobiotic in the body of experimental animals is a first step of the biochemical pathway of the formation of DNA adducts which might lead to the development of cancer. Fundamental in the extrapolation from one species to another is the characterisation of processes by means of population parameters. Nevertheless, the consideration of individual parameters varying between repeated experiments and different doses is of great importance to obtain a more precise insight into the variability structure of the process so that a valid basis for further research is the final result. Two nonlinear four-stage hierarchical models for a repeated measurement design and for repeated exposures to different doses are presented. The estimation of the individual and population parameters as well as of the covariance matrices is performed by an EM algorithm.
- Language
-
Englisch
- Bibliographic citation
-
Series: Technical Report ; No. 2000,01
- Subject
-
ethylene
ethylene oxide
risk assessment
toxicokinetics
population parameters
two-compartment model
nonlinear hierarchical model
Bayes estimates
EM algorithm
repeated measurement
- Event
-
Geistige Schöpfung
- (who)
-
Selinski, Silvia
- Event
-
Veröffentlichung
- (who)
-
Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen
- (where)
-
Dortmund
- (when)
-
2000
- Handle
- Last update
-
10.03.2025, 11:41 AM CET
Data provider
ZBW - Deutsche Zentralbibliothek für Wirtschaftswissenschaften - Leibniz-Informationszentrum Wirtschaft. If you have any questions about the object, please contact the data provider.
Object type
- Arbeitspapier
Associated
- Selinski, Silvia
- Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen
Time of origin
- 2000
Other Objects (12)
Estimation of toxicokinetic population parameters in a four-stage hierarchical model
Bayes estimation of toxicokinetic parameters in a four-stage hierarchical model
The four stages of cruelty
Hierarchical time-varying estimation of asset pricing models
Hierarchical IPF: Generating a synthetic population for Switzerland
On the structure and estimation of hierarchical Archimedean copulas
Franz Kafka's "The Trial": four stage adaptions
Population estimation utilizing Earth Observation data
Hierarchical population genomic structure of bacterial pathogens in EnteroBase
Hierarchical language modeling for one-stage stochastic interpretation of natural speech
Exact Sampling and Unbiased Estimation in the Hierarchical Pitman-Yor Process
Hierarchical time varying estimation of a multi factor asset pricing model
Estimation of toxicokinetic population parameters in a four-stage hierarchical model
Bayes estimation of toxicokinetic parameters in a four-stage hierarchical model
The four stages of cruelty
Hierarchical time-varying estimation of asset pricing models
Hierarchical IPF: Generating a synthetic population for Switzerland
On the structure and estimation of hierarchical Archimedean copulas
Franz Kafka's "The Trial": four stage adaptions
Population estimation utilizing Earth Observation data
Hierarchical population genomic structure of bacterial pathogens in EnteroBase
Hierarchical language modeling for one-stage stochastic interpretation of natural speech
Exact Sampling and Unbiased Estimation in the Hierarchical Pitman-Yor Process
Hierarchical time varying estimation of a multi factor asset pricing model
Estimation of toxicokinetic population parameters in a four-stage hierarchical model
Bayes estimation of toxicokinetic parameters in a four-stage hierarchical model
The four stages of cruelty
Hierarchical time-varying estimation of asset pricing models
Hierarchical IPF: Generating a synthetic population for Switzerland
On the structure and estimation of hierarchical Archimedean copulas
Franz Kafka's "The Trial": four stage adaptions
Population estimation utilizing Earth Observation data
Hierarchical population genomic structure of bacterial pathogens in EnteroBase
Hierarchical language modeling for one-stage stochastic interpretation of natural speech
Exact Sampling and Unbiased Estimation in the Hierarchical Pitman-Yor Process