Downregulation of stromal syntenin sustains AML development

Abstract: The crosstalk between cancer and stromal cells plays a critical role in tumor progression. Syntenin is a small scaffold protein involved in the regulation of intercellular communication that is emerging as a target for cancer therapy. Here, we show that certain aggressive forms of acute myeloid leukemia (AML) reduce the expression of syntenin in bone marrow stromal cells (BMSC). Stromal syntenin deficiency, in turn, generates a pro‐tumoral microenvironment. From serial transplantations in mice and co‐culture experiments, we conclude that syntenin‐deficient BMSC stimulate AML aggressiveness by promoting AML cell survival and protein synthesis. This pro‐tumoral activity is supported by increased expression of endoglin, a classical marker of BMSC, which in trans stimulates AML translational activity. In short, our study reveals a vicious signaling loop potentially at the heart of AML–stroma crosstalk and unsuspected tumor‐suppressive effects of syntenin that need to be considered during systemic targeting of syntenin in cancer therapy.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Downregulation of stromal syntenin sustains AML development ; day:11 ; month:10 ; year:2023 ; extent:22 ; EMBO molecular medicine / European Molecular Biology Organization ; (11.10.2023) (gesamt 22)

Contributors, Places and Time

• Creator: Leblanc, Raphael ; Ghossoub, Rania ; Goubard, Armelle ; Castellano, Rémy ; Fares, Joanna ; Camoin, Luc ; Audebert, Stephane ; Balzano, Marielle ; Bou‐Tayeh, Berna ; Fauriat, Cyril ; Vey, Norbert ; Garciaz, Sylvain ; Borg, Jean‐Paul ; Collette, Yves ; Aurrand‐Lions, Michel ; David, Guido ; Zimmermann, Pascale

Further information

• DOI: 10.15252/emmm.202317570
• URN: urn:nbn:de:101:1-2023101215010744666382
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:48 AM CEST