Synthetic and Crystallographic Insight into Exploiting sp 2 Hybridization in the Development of α‐ l ‐Fucosidase Inhibitors
Abstract: The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, α‐l‐fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel α‐l‐fucosidase inhibitors, with X‐ray crystallographic analysis using an α‐l‐fucosidase from Bacteroides thetaiotamicron helping to lay a foundation for future development of inhibitors for this important enzyme class.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Synthetic and Crystallographic Insight into Exploiting sp 2 Hybridization in the Development of α‐ l ‐Fucosidase Inhibitors ; volume:20 ; number:11 ; year:2019 ; pages:1365-1368 ; extent:4
ChemBioChem ; 20, Heft 11 (2019), 1365-1368 (gesamt 4)
- Creator
- DOI
-
10.1002/cbic.201800710
- URN
-
urn:nbn:de:101:1-2022080108065713749553
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:28 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Coyle, Travis
- Wu, Liang
- Debowski, Aleksandra W.
- Davies, Gideon
- Stubbs, Keith A.
Other Objects (12)
Hot work tool steel in laser powder bed fusion : from parameter optimization to quality monitoring in industrial application
Hot work tool steel in laser powder bed fusion : from parameter optimization to quality monitoring in industrial application
Peroral endoscopic myotomy and simultaneous endoscopic diverticuloseptotomy in a case of achalasia with diverticula
Ultrabroadband sampling circuits in SiGe BiCMOS technology for time interleaved analog-to-digital converter
Vitamin D and the microbiota connection: understanding its potential to improve COPD outcomes
A New Default Intensity Model with Fuzziness and Hesitation
Experiments and simulation of block motion in underwater bench blasting
Preparation of hollow bioactive glass nanofibers by a facile electrospinning method
Neuromodulation in the intensive care unit
Effects of heat treatment on microstructure and properties of CrVNiAlCu high-entropy alloy
Low-complexity beam-domain channel estimation and power allocation in hybrid architecture massive MIMO systems
Pricing for a basket of LCDS under fuzzy environments
Hot work tool steel in laser powder bed fusion : from parameter optimization to quality monitoring in industrial application
Hot work tool steel in laser powder bed fusion : from parameter optimization to quality monitoring in industrial application
Peroral endoscopic myotomy and simultaneous endoscopic diverticuloseptotomy in a case of achalasia with diverticula
Ultrabroadband sampling circuits in SiGe BiCMOS technology for time interleaved analog-to-digital converter
Vitamin D and the microbiota connection: understanding its potential to improve COPD outcomes
A New Default Intensity Model with Fuzziness and Hesitation
Experiments and simulation of block motion in underwater bench blasting
Preparation of hollow bioactive glass nanofibers by a facile electrospinning method
Neuromodulation in the intensive care unit
Effects of heat treatment on microstructure and properties of CrVNiAlCu high-entropy alloy
Low-complexity beam-domain channel estimation and power allocation in hybrid architecture massive MIMO systems
Pricing for a basket of LCDS under fuzzy environments
Hot work tool steel in laser powder bed fusion : from parameter optimization to quality monitoring in industrial application
Hot work tool steel in laser powder bed fusion : from parameter optimization to quality monitoring in industrial application
Peroral endoscopic myotomy and simultaneous endoscopic diverticuloseptotomy in a case of achalasia with diverticula
Ultrabroadband sampling circuits in SiGe BiCMOS technology for time interleaved analog-to-digital converter
Vitamin D and the microbiota connection: understanding its potential to improve COPD outcomes
A New Default Intensity Model with Fuzziness and Hesitation
Experiments and simulation of block motion in underwater bench blasting
Preparation of hollow bioactive glass nanofibers by a facile electrospinning method
Neuromodulation in the intensive care unit
Effects of heat treatment on microstructure and properties of CrVNiAlCu high-entropy alloy
Low-complexity beam-domain channel estimation and power allocation in hybrid architecture massive MIMO systems