Detection of Abdominal Lymph Node Metastasis from Pancreatic Neuroendocrine Tumor by Somatostatin Receptor Scintigraphy: Comparison with Somatostatin Receptor Type 2 Immunostaining

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We report a 58-year-old male with a histopathologically proven grade 2 (G2) pancreatic neuroendocrine neoplasm and multiple abdominal node metastases by use of a laparoscopic pancreatic body and tail resection procedure, plus abdominal lymph node dissection. A primary pancreatic tail neuroendocrine tumor sized 20 × 25 mm was detected by contrast-enhanced computed tomography, somatostatin receptor scintigraphy (SRS), and fluorodeoxyglucose positron emission tomography (FDG-PET) examinations and pathologically diagnosed as a pancreatic neuroendocrine tumor (PNET, G2) based on positive immunostaining for somatostatin receptor (SSTR) type 2. Of three metastatic histopathological lymph nodes, two measured 18 × 21 and 10 × 12 mm, respectively, with whole strong SSTR immunostaining showing moderate uptake in SRS findings, whereas the other node, sized 8 × 10 mm, had strong SSTR immunostaining only in a small 6 × 6-mm-sized portion and showed no uptake in SRS findings, likely because of the limited spatial resolution of scintigraphy. On the other hand, only the largest node (18 × 21 mm) was visualized by FDG-PET. SRS may be useful for metastatic lymph node diagnosis based on SSTR immunostaining, though a disadvantage is the spatial resolution limitation.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Detection of Abdominal Lymph Node Metastasis from Pancreatic Neuroendocrine Tumor by Somatostatin Receptor Scintigraphy: Comparison with Somatostatin Receptor Type 2 Immunostaining ; volume:16 ; number:1 ; year:2023 ; pages:543-549 ; extent:7
Case reports in oncology ; 16, Heft 1 (2023), 543-549 (gesamt 7)

Urheber
Kitajima, Kazuhiro
Shiomi, Hideyuki
Kihara, Takako
Hirono, Seiko
Nakano, Ryota
Okamoto, Tomohiro
Yagi, Chisako
Eda, Hirotsugu
Matsuda, Kosuke
Hatano, Michiko
Yoshida, Makoto
Kono, Hiroshi
Hirota, Seiichi
Minami, Tetsuya
Yamakado, Koichiro

DOI
10.1159/000531572
URN
urn:nbn:de:101:1-2023122723494134619667
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:49 MESZ

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Beteiligte

  • Kitajima, Kazuhiro
  • Shiomi, Hideyuki
  • Kihara, Takako
  • Hirono, Seiko
  • Nakano, Ryota
  • Okamoto, Tomohiro
  • Yagi, Chisako
  • Eda, Hirotsugu
  • Matsuda, Kosuke
  • Hatano, Michiko
  • Yoshida, Makoto
  • Kono, Hiroshi
  • Hirota, Seiichi
  • Minami, Tetsuya
  • Yamakado, Koichiro

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