Analysis of some pharmaceuticals in the presence of their synthetic impurities by applying hybrid micelle liquid chromatography
Abstract: A stability-indicating hybrid micelle liquid chromatography accompanied by UV detection was developed for the simultaneous analysis of either paracetamol (PCA) or pseudoephedrine hydrochloride (PSU) with their synthetic impurities. Mixture I contains PCA with p-amino phenol and p-nitro phenol, while mixture II involves the estimation of PSU with benzaldehyde and benzoic acid. Both mixtures were separated using a C18 column that was thermostatically maintained at 40°C and operating under a flow rate of 1.5 mL/min, applying UV detection at 240 nm for mixture I and 220 nm for mixture II. In both cases, the mobile phase consisted of 0.1 M sodium dodecyl sulfate, acetonitrile, and triethylamine (90:10:0.3, v/v/v) and adjusted to pH 4 (mixture I) or pH 3.7 (mixture II) using 2.0 M O-phosphoric acid. The proposed method was validated and successfully applied to assay different pharmaceuticals containing PCA or PSU. Moreover, the stability-indicating nature of the proposed method was proved through applying photolytic degradation procedures for PCA.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Analysis of some pharmaceuticals in the presence of their synthetic impurities by applying hybrid micelle liquid chromatography ; volume:18 ; number:1 ; year:2020 ; pages:377-390 ; extent:14
Open chemistry ; 18, Heft 1 (2020), 377-390 (gesamt 14)
- Creator
-
El Sherbiny, Dina
Wahba, Mary E. K.
- DOI
-
10.1515/chem-2020-0041
- URN
-
urn:nbn:de:101:1-2410161727100.437828095419
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:23 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- El Sherbiny, Dina
- Wahba, Mary E. K.
Other Objects (12)
Applying a risk assessment guided evaluation for verifying comprehensive two-dimensional gas chromatography to analyse complex pharmaceuticals
A fast determination of yohimbine in pharmaceuticals by micellar electrokinetic chromatography
Abelian Chern-Simons vortices in the presence of magnetic impurities
Applicability of specific surface area determination on pharmaceuticals by inverse gas chromatography
Quantification of organic volatile impurities in Oseltamivir phosphate drug substances by head space gas chromatography
Excellent removal of knob-into-hole bispecific antibody byproducts and impurities in a single-capture chromatography
Vortices and impurities
Women and pharmaceuticals
Zolyse (Alcon Pharmaceuticals)
In silico toxicity assessment and trace level quantification of two genotoxic impurities in silodosin using capillary gas chromatography
Tackling the Nitrosamine Crisis - Supercritical Fluid Chromatography Coupled with Mass Spectrometry for the Determination of Unexpected Drug Impurities
Analysis of weakly chromophore impurities by means of liquid chromatography coupled with charged aerosol detection and mass spectrometry
Applying a risk assessment guided evaluation for verifying comprehensive two-dimensional gas chromatography to analyse complex pharmaceuticals
A fast determination of yohimbine in pharmaceuticals by micellar electrokinetic chromatography
Abelian Chern-Simons vortices in the presence of magnetic impurities
Applicability of specific surface area determination on pharmaceuticals by inverse gas chromatography
Quantification of organic volatile impurities in Oseltamivir phosphate drug substances by head space gas chromatography
Excellent removal of knob-into-hole bispecific antibody byproducts and impurities in a single-capture chromatography
Vortices and impurities
Women and pharmaceuticals
Zolyse (Alcon Pharmaceuticals)
In silico toxicity assessment and trace level quantification of two genotoxic impurities in silodosin using capillary gas chromatography
Tackling the Nitrosamine Crisis - Supercritical Fluid Chromatography Coupled with Mass Spectrometry for the Determination of Unexpected Drug Impurities
Analysis of weakly chromophore impurities by means of liquid chromatography coupled with charged aerosol detection and mass spectrometry
Applying a risk assessment guided evaluation for verifying comprehensive two-dimensional gas chromatography to analyse complex pharmaceuticals
A fast determination of yohimbine in pharmaceuticals by micellar electrokinetic chromatography
Abelian Chern-Simons vortices in the presence of magnetic impurities
Applicability of specific surface area determination on pharmaceuticals by inverse gas chromatography
Quantification of organic volatile impurities in Oseltamivir phosphate drug substances by head space gas chromatography
Excellent removal of knob-into-hole bispecific antibody byproducts and impurities in a single-capture chromatography
Vortices and impurities
Women and pharmaceuticals
Zolyse (Alcon Pharmaceuticals)
In silico toxicity assessment and trace level quantification of two genotoxic impurities in silodosin using capillary gas chromatography
Tackling the Nitrosamine Crisis - Supercritical Fluid Chromatography Coupled with Mass Spectrometry for the Determination of Unexpected Drug Impurities