Sequential Methods for Di‐ and Tetrahydro‐Pyranone Synthesis Enable Concise Access to Tuscolid δ‐Lactone
Abstract: Two novel tandem sequences for stereoselective synthesis of elaborate hydropyranones are reported. The first one relies on an aldol‐lactonization procedure of a chiral enolate with an unprotected aldehyde, while the second one is based on a challenging dienolate ketone addition with concomitant cyclization and substrate controlled reduction. Both approaches proceed with high efficiency and stereoselectivity and enable very short accesses to the authentic pyranone subunit of the complex polyketide tuscolid and will be important to develop a first total synthesis of this structurally unique macrolide and to evaluate the tuscolid‐tuscoron rearrangement.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Sequential Methods for Di‐ and Tetrahydro‐Pyranone Synthesis Enable Concise Access to Tuscolid δ‐Lactone ; day:13 ; month:01 ; year:2023 ; extent:6
Chemistry ; (13.01.2023) (gesamt 6)
- Urheber
- DOI
-
10.1002/asia.202201193
- URN
-
urn:nbn:de:101:1-2023011414203433251859
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:30 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Gao, Xin
- Menche, Dirk
Ähnliche Objekte (12)
SRPX2 attenuated oxygen–glucose deprivation and reperfusion-induced injury in cardiomyocytes via alleviating endoplasmic reticulum stress-induced apoptosis through targeting PI3K/Akt/mTOR axis
Exploring the effects of missing data on the estimation of fractal and multifractal parameters based on bootstrap method
Parent-implemented interventions in Chinese families of children with autism spectrum disorder
Decomposition of the total effect for two mediators: A natural mediated interaction effect framework
Analysis of the effects of related fingerprints on molecular similarity using an eigenvalue entropy approach
Decomposition of the total effect for two mediators: A natural mediated interaction effect framework
Nonparametric tests for differential gene expression and interaction effects in multi-factorial microarray experiments
Safety considerations and time constant determined extended operations for fuel cell-powered aircrafts
A protein-dependent side-chain rotamer library
Evaluating the impact of remittances on human capital investment in the Kyrgyz Republic
Novel non-periodic spoof surface plasmon polaritons with H-shaped cells and its application to high selectivity wideband bandpass filter
On missing Bianchi identities in cohomology formulation
SRPX2 attenuated oxygen–glucose deprivation and reperfusion-induced injury in cardiomyocytes via alleviating endoplasmic reticulum stress-induced apoptosis through targeting PI3K/Akt/mTOR axis
Exploring the effects of missing data on the estimation of fractal and multifractal parameters based on bootstrap method
Parent-implemented interventions in Chinese families of children with autism spectrum disorder
Decomposition of the total effect for two mediators: A natural mediated interaction effect framework
Analysis of the effects of related fingerprints on molecular similarity using an eigenvalue entropy approach
Decomposition of the total effect for two mediators: A natural mediated interaction effect framework
Nonparametric tests for differential gene expression and interaction effects in multi-factorial microarray experiments
Safety considerations and time constant determined extended operations for fuel cell-powered aircrafts
A protein-dependent side-chain rotamer library
Evaluating the impact of remittances on human capital investment in the Kyrgyz Republic
Novel non-periodic spoof surface plasmon polaritons with H-shaped cells and its application to high selectivity wideband bandpass filter
On missing Bianchi identities in cohomology formulation
SRPX2 attenuated oxygen–glucose deprivation and reperfusion-induced injury in cardiomyocytes via alleviating endoplasmic reticulum stress-induced apoptosis through targeting PI3K/Akt/mTOR axis
Exploring the effects of missing data on the estimation of fractal and multifractal parameters based on bootstrap method
Parent-implemented interventions in Chinese families of children with autism spectrum disorder
Decomposition of the total effect for two mediators: A natural mediated interaction effect framework
Analysis of the effects of related fingerprints on molecular similarity using an eigenvalue entropy approach
Decomposition of the total effect for two mediators: A natural mediated interaction effect framework
Nonparametric tests for differential gene expression and interaction effects in multi-factorial microarray experiments
Safety considerations and time constant determined extended operations for fuel cell-powered aircrafts
A protein-dependent side-chain rotamer library
Evaluating the impact of remittances on human capital investment in the Kyrgyz Republic
Novel non-periodic spoof surface plasmon polaritons with H-shaped cells and its application to high selectivity wideband bandpass filter