Fucose Binding Motifs on Mucin Core Glycopeptides Impact Bacterial Lectin Recognition **
Abstract: Mucin glycoproteins are essential components of the mucosal barrier, which protects the host from pathogens. Throughout evolution, bacteria have developed strategies to modulate and penetrate this barrier, and cause virulence by interacting with mucin O‐glycans at the epithelial cell‐surface. O‐fucosylated glycan epitopes on mucins are key ligands of many bacterial lectins. Here, a chemoenzymatic synthesis strategy is described to prepare a library of fucosylated mucin core glycopeptides to enable studies of mucin‐interacting and fucose‐binding bacterial lectins. Glycan cores with biologically important Lewis and H‐antigens were prepared decorating the peptide backbone at different sites and densities. The fucosylated mucin glycopeptides were applied in microarray binding studies to explore the importance of glycan core and peptide backbone presentation of these antigens in binding interactions with the P. aeruginosa lectin LecB and the C. difficile toxin A.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Fucose Binding Motifs on Mucin Core Glycopeptides Impact Bacterial Lectin Recognition ** ; day:17 ; month:05 ; year:2023 ; extent:13
Angewandte Chemie ; (17.05.2023) (gesamt 13)
- Creator
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Behren, Sandra
Yu, Jin
Pett, Christian
Schorlemer, Manuel
Heine, Viktoria
Fischöder, Thomas
Elling, Lothar
Westerlind, Ulrika
- DOI
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10.1002/ange.202302437
- URN
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urn:nbn:de:101:1-2023051715375876479374
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:47 AM CEST
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Associated
- Behren, Sandra
- Yu, Jin
- Pett, Christian
- Schorlemer, Manuel
- Heine, Viktoria
- Fischöder, Thomas
- Elling, Lothar
- Westerlind, Ulrika
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Fucose Binding Motifs on Mucin Core Glycopeptides Impact Bacterial Lectin Recognition **
Fucose Binding Motifs on Mucin Core Glycopeptides Impact Bacterial Lectin Recognition**
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Fremdproteine auf Rohwolle, Waschwolle und Kammzug - ihre Abtrennung und Charakterisierung
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Fucose Binding Motifs on Mucin Core Glycopeptides Impact Bacterial Lectin Recognition **
Fucose Binding Motifs on Mucin Core Glycopeptides Impact Bacterial Lectin Recognition**
Bacteria Lectin Recognition Towards Fucose Binding Motifs Highlights the Impact of Presenting Mucin Core Glycopeptides
Fremdproteine auf Rohwolle, Waschwolle und Kammzug - ihre Abtrennung und Charakterisierung
Gram‐Scale Production of GDP‐β‐ l‐ fucose with Multi‐Enzyme Cascades in a Repetitive‐Batch Mode
Gram-Scale Production of GDP-β-l-fucose with Multi-Enzyme Cascades in a Repetitive-Batch Mode
Biotinylated N-Acetyllactosamine- and N,N-Diacetyllactosamine-Based Oligosaccharides as Novel Ligands for Human Galectin-3
Cellular response and clearance mechanisms triggered by protein-mineral complexes
How to engineer an organic solvent tolerant lipase: insights from directed evolution and molecular dynamics simulations
Protein engineering for polyethylene terephthalate degradation
Investigations on transglycosylation reactions of glycosidases and glycosynthases for the syntheses of (poly-)N-acetyllactosamine glycans