B cell immunity in lung transplant rejection - effector mechanisms and therapeutic implications
Abstract: Allograft rejection remains the major hurdle in lung transplantation despite modern immunosuppressive treatment. As part of the alloreactive process, B cells are increasingly recognized as modulators of alloimmunity and initiators of a donor-specific humoral response. In chronically rejected lung allografts, B cells contribute to the formation of tertiary lymphoid structures and promote local alloimmune responses. However, B cells are functionally heterogeneous and some B cell subsets may promote alloimmune tolerance. In this review, we describe the current understanding of B-cell-dependent mechanisms in pulmonary allograft rejection and highlight promising future strategies that employ B cell-targeted therapies
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Frontiers in immunology. - 13 (2022) , 845867, ISSN: 1664-3224
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
-
Universität
- (wann)
-
2022
- Urheber
- DOI
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10.3389/fimmu.2022.845867
- URN
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urn:nbn:de:bsz:25-freidok-2257116
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:47 MEZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
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Beteiligte
- Ohm, Birte
- Jungraithmayr, Wolfgang
- Universität
Entstanden
- 2022
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