Probing Site‐Selective Conjugation Chemistries for the Construction of Homogeneous Synthetic Glycodendriproteins
Abstract: Methods that site‐selectively attach multivalent carbohydrate moieties to proteins can be used to generate homogeneous glycodendriproteins as synthetic functional mimics of glycoproteins. Here, we study aspects of the scope and limitations of some common bioconjugation techniques that can give access to well‐defined glycodendriproteins. A diverse reactive platform was designed via use of thiol‐Michael‐type additions, thiol‐ene reactions, and Cu (I)‐mediated azide‐alkyne cycloadditions from recombinant proteins containing the non‐canonical amino acids dehydroalanine, homoallylglycine, homopropargylglycine, and azidohomoalanine.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Probing Site‐Selective Conjugation Chemistries for the Construction of Homogeneous Synthetic Glycodendriproteins ; day:01 ; month:04 ; year:2022 ; extent:1
ChemBioChem ; (01.04.2022) (gesamt 1)
- Urheber
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Cobo, Isidro
Matheu, M. Isabel
Castillón, Sergio
Davis, Benjamin G.
Boutureira, Omar
- DOI
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10.1002/cbic.202200020
- URN
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urn:nbn:de:101:1-2022040415471599988441
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:22 MESZ
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Beteiligte
- Cobo, Isidro
- Matheu, M. Isabel
- Castillón, Sergio
- Davis, Benjamin G.
- Boutureira, Omar
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