Photochemical “In‐Air” Combinatorial Discovery of Antimicrobial Co‐polymers
Abstract: There is an urgent need to identify new, non‐traditional antimicrobials. The discovery of new polymeric antimicrobials is limited by current low‐throughput synthetic tools, which means that limited chemical space has been explored. Herein, we employ photochemical “in‐air” reversible addition–fragmentation chain‐transfer (RAFT) polymerization with microwell plates, using liquid‐handling robots to assemble large libraries of cationic polymers, without the need for degassing or purification steps, facilitating transfer to screening. Several lead polymers were identified including a co‐polymer with propylene glycol side chains with significantly enhanced antimicrobial activity and increased therapeutic window. Mechanistic studies showed that this polymer was bacteriostatic, and surprisingly did not lyse the cell membranes, implying an alternative mode of action. This versatile method using simple robotics will help to develop new biomaterials with emergent properties.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Photochemical “In‐Air” Combinatorial Discovery of Antimicrobial Co‐polymers ; volume:24 ; number:52 ; year:2018 ; pages:13758-13761 ; extent:4
Chemistry - a European journal ; 24, Heft 52 (2018), 13758-13761 (gesamt 4)
- Urheber
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Richards, Sarah‐Jane
Jones, Adam
Tomás, Ruben M. F.
Gibson, Matthew I.
- DOI
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10.1002/chem.201802594
- URN
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urn:nbn:de:101:1-2022082107042398413977
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:28 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Richards, Sarah‐Jane
- Jones, Adam
- Tomás, Ruben M. F.
- Gibson, Matthew I.
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