Immunological predictors of dimethyl fumarate‐induced lymphopenia
Abstract: Treatment with dimethyl fumarate (DMF) leads to lymphopenia and infectious complications in a subset of patients with multiple sclerosis (MS). Here, we aimed to reveal immune markers of DMF-associated lymphopenia. This prospective observational study longitudinally assessed 31 individuals with MS by single-cell mass cytometry before and after 12 and 48 weeks of DMF therapy. Employing a neural network-based representation learning approach, we identified a CCR4-expressing T helper cell population negatively associated with relevant lymphopenia. CCR4-expressing T helper cells represent a candidate prognostic biomarker for the development of relevant lymphopenia in patients undergoing DMF treatment. ANN NEUROL 2022;91:676–681
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Annals of neurology. - 91, 5 (2022) , 676-681, ISSN: 1531-8249
- Classification
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Medizin, Gesundheit
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2022
- Creator
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Diebold, Martin
Galli, Edoardo
Kopf, Andreas
Sanderson, Nicholas
Callegari, Ilaria
Ingelfinger, Florian
Gonzalo Núñez, Nicolás
Benkert, Pascal
Kappos, Ludwig
Kuhle, Jens
Becher, Burkhard
Claassen, Manfred
Derfuß, Tobias
- DOI
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10.1002/ana.26328
- URN
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urn:nbn:de:bsz:25-freidok-2260917
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:35 AM CEST
Data provider
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Associated
- Diebold, Martin
- Galli, Edoardo
- Kopf, Andreas
- Sanderson, Nicholas
- Callegari, Ilaria
- Ingelfinger, Florian
- Gonzalo Núñez, Nicolás
- Benkert, Pascal
- Kappos, Ludwig
- Kuhle, Jens
- Becher, Burkhard
- Claassen, Manfred
- Derfuß, Tobias
- Universität
Time of origin
- 2022
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Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice
Dimethyl fumarate inhibits antibody-induced platelet destruction in immune thrombocytopenia mouse
Effects of dimethyl fumarate on neuroprotection and immunomodulation
Dimethyl fumarate reduces TNF and Plasmodium falciparum induced brain endothelium activation in vitro
Pharmacokinetics and Bioavailability of Monomethyl Fumarate Following a Single Oral Dose of Bafiertam™ (Monomethyl Fumarate) or Tecfidera® (Dimethyl Fumarate)
CMV meningitis associated with dimethyl fumarate therapy-induced lymphopenia in a multiple sclerosis patient
CMV meningitis associated with dimethyl fumarate therapy-induced lymphopenia in a multiple sclerosis patient
Effects of dimethyl fumarate in two animal models of MS
Gut microbiota composition as a candidate risk factor for dimethyl fumarate-induced lymphopenia in multiple sclerosis
Dimethyl fumarate suppresses Tc17 cell fate in autoimmunity via ROS accumulation
Predictors of lymphocyte count recovery after dimethyl fumarate-induced lymphopenia in people with multiple sclerosis
Dimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice
Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice
Dimethyl fumarate inhibits antibody-induced platelet destruction in immune thrombocytopenia mouse
Effects of dimethyl fumarate on neuroprotection and immunomodulation
Dimethyl fumarate reduces TNF and Plasmodium falciparum induced brain endothelium activation in vitro
Pharmacokinetics and Bioavailability of Monomethyl Fumarate Following a Single Oral Dose of Bafiertam™ (Monomethyl Fumarate) or Tecfidera® (Dimethyl Fumarate)
CMV meningitis associated with dimethyl fumarate therapy-induced lymphopenia in a multiple sclerosis patient
CMV meningitis associated with dimethyl fumarate therapy-induced lymphopenia in a multiple sclerosis patient
Effects of dimethyl fumarate in two animal models of MS
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