The phytochemical plumbagin reciprocally modulates osteoblasts and osteoclasts
Abstract: Bone metabolism is essential for maintaining bone mineral density and bone strength through a balance between bone formation and bone resorption. Bone formation is associated with osteoblast activity whereas bone resorption is linked to osteoclast differentiation. Osteoblast progenitors give rise to the formation of mature osteoblasts whereas monocytes are the precursors for multi-nucleated osteoclasts. Chronic inflammation, auto-inflammation, hormonal changes or adiposity have the potential to disturb the balance between bone formation and bone loss. Several plant-derived components are described to modulate bone metabolism and alleviate osteoporosis by enhancing bone formation and inhibiting bone resorption. The plant-derived naphthoquinone plumbagin is a bioactive compound that can be isolated from the roots of the Plumbago genus. It has been used as traditional medicine for treating infectious diseases, rheumatoid arthritis and dermatological diseases. Reportedly, plumbagin exerts its biological activities primarily through induction of reactive oxygen species and triggers osteoblast-mediated bone formation. It is plausible that plumbagin’s reciprocal actions – inhibiting or inducing death in osteoclasts but promoting survival or growth of osteoblasts – are a function of the synergy with bone-metabolizing hormones calcitonin, Parathormone and vitamin D. Herein, we develop a framework for plausible molecular modus operandi of plumbagin in bone metabolism.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
The phytochemical plumbagin reciprocally modulates osteoblasts and osteoclasts ; volume:403 ; number:2 ; year:2022 ; pages:211-229 ; extent:019
Biological chemistry ; 403, Heft 2 (2022), 211-229 (gesamt 019)
- Urheber
-
Yadav, Avinash M.
Bagade, Manali M.
Ghumnani, Soni
Raman, Sujatha
Saha, Bhaskar
Hieke-Kubatzky, Katharina
Ashma, Richa
- DOI
-
10.1515/hsz-2021-0290
- URN
-
urn:nbn:de:101:1-2408061628572.639146838798
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 10:50 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Yadav, Avinash M.
- Bagade, Manali M.
- Ghumnani, Soni
- Raman, Sujatha
- Saha, Bhaskar
- Hieke-Kubatzky, Katharina
- Ashma, Richa
Ähnliche Objekte (12)
Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts
The Differential Effect of Metformin on Osteocytes, Osteoblasts, and Osteoclasts
In vitro effects of pantoprazole on human osteoblasts and osteoclasts
Trans-pairing between osteoclasts and osteoblasts shapes the cranial base during development
Osteoblasts and osteoclasts: an important switch of tumour cell dormancy during bone metastasis
Potential anti-osteoporotic effects of herbal extracts on osteoclasts, osteoblasts and chondrocytes in vitro
Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells
Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts
Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
Exosomes play a role in multiple myeloma bone disease and tumor development by targeting osteoclasts and osteoblasts
Upregulating MicroRNA-410 or Downregulating Wnt-11 Increases Osteoblasts and Reduces Osteoclasts to Alleviate Osteonecrosis of the Femoral Head
Genistein contributes to cell cycle progression and regulates oxidative stress in primary culture of osteoblasts along with osteoclasts attenuation
Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts
The Differential Effect of Metformin on Osteocytes, Osteoblasts, and Osteoclasts
In vitro effects of pantoprazole on human osteoblasts and osteoclasts
Trans-pairing between osteoclasts and osteoblasts shapes the cranial base during development
Osteoblasts and osteoclasts: an important switch of tumour cell dormancy during bone metastasis
Potential anti-osteoporotic effects of herbal extracts on osteoclasts, osteoblasts and chondrocytes in vitro
Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells
Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts
Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
Exosomes play a role in multiple myeloma bone disease and tumor development by targeting osteoclasts and osteoblasts
Upregulating MicroRNA-410 or Downregulating Wnt-11 Increases Osteoblasts and Reduces Osteoclasts to Alleviate Osteonecrosis of the Femoral Head
Genistein contributes to cell cycle progression and regulates oxidative stress in primary culture of osteoblasts along with osteoclasts attenuation
Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts
The Differential Effect of Metformin on Osteocytes, Osteoblasts, and Osteoclasts
In vitro effects of pantoprazole on human osteoblasts and osteoclasts
Trans-pairing between osteoclasts and osteoblasts shapes the cranial base during development
Osteoblasts and osteoclasts: an important switch of tumour cell dormancy during bone metastasis
Potential anti-osteoporotic effects of herbal extracts on osteoclasts, osteoblasts and chondrocytes in vitro
Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells
Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts
Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
Exosomes play a role in multiple myeloma bone disease and tumor development by targeting osteoclasts and osteoblasts
Upregulating MicroRNA-410 or Downregulating Wnt-11 Increases Osteoblasts and Reduces Osteoclasts to Alleviate Osteonecrosis of the Femoral Head