Modulation of dynamin function by small molecules

Abstract: Dynamins are essential as membrane remodelers in various cellular processes, like receptor-mediated endocytosis, synaptic vesicle recycling and spermatogenesis. Moreover, dynamin is involved in the internalization of numerous viruses and in the motility of several cancer cell lines. As tools for dissecting the underlying mechanisms of these important biological processes and as potential future therapeutics, small molecules have been developed in the last two decades that modulate the functions of dynamin. In this review we give an overview of the compound classes that are currently in use and describe how they affect dynamin function.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Modulation of dynamin function by small molecules ; volume:399 ; number:12 ; year:2018 ; pages:1421-1432 ; extent:12 ; Biological chemistry ; 399, Heft 12 (2018), 1421-1432 (gesamt 12)

Contributors, Places and Time

• Creator: Eschenburg, Susanne ; Reubold, Thomas F.

Further information

• DOI: 10.1515/hsz-2018-0257
• URN: urn:nbn:de:101:1-2408061544242.795842655813
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:52 AM CEST