Exploiting Hydroxamic Acids as Organocatalysts for the Epoxidation of Alkenes with Hydrogen Peroxide as the Oxidant

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Abstract: The epoxidation of alkenes has altered and reshaped the way scientists think in modern organic synthesis. Herein, a novel, sustainable and eco‐friendly protocol for the epoxidation of alkenes is reported, utilizing hydrogen peroxide as the green oxidant and, for the first time, hydroxamic acid derivatives as the organocatalyst. The presented methodology is very effective, leading to good to high yields for the oxidation of a variety of olefins, while various functional groups are well tolerated. Mechanistic studies utilizing direct infusion high resolution mass spectrometry (DI‐HRMS) provide strong evidence for the mechanism of the organocatalytic oxidation.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Exploiting Hydroxamic Acids as Organocatalysts for the Epoxidation of Alkenes with Hydrogen Peroxide as the Oxidant ; day:26 ; month:02 ; year:2024 ; extent:12
European journal of organic chemistry ; (26.02.2024) (gesamt 12)

Creator: Poursaitidis, Efthymios T.
Trigka, Foteini
Mantzourani, Christiana
Kokotou, Maroula G.
Triandafillidi, Ierasia
Kokotos, Christoforos

DOI: 10.1002/ejoc.202400082

URN: urn:nbn:de:101:1-2024022714075525478713

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:52 AM CEST

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Poursaitidis, Efthymios T.
Trigka, Foteini
Mantzourani, Christiana
Kokotou, Maroula G.
Triandafillidi, Ierasia
Kokotos, Christoforos

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Exploiting Hydroxamic Acids as Organocatalysts for the Epoxidation of Alkenes with Hydrogen Peroxide as the Oxidant

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Other Objects (12)

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