Reduced penetrance of Parkinson’s disease models

Abstract: The etiology and progression of Parkinson’s Disease (PD), the second most prevalent neurological disorder, have been widely investigated for several decades; however, a cure is still lacking. Despite the development of several neurotoxins and animal models to study this rather heterogeneous disease, a complete recapitulation of the neurophysiology and neuropathology of PD has not been fully achieved. One underlying cause for this could be that mutations in PD-associated genes have reduced penetrance. Therefore, the quest for novel PD models is required where a double hit approach needs to be evoked – a combination of genetic alterations and environmental factors need to be accounted for in one unique model simultaneously.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Reduced penetrance of Parkinson’s disease models ; volume:34 ; number:2 ; year:2022 ; pages:117-124 ; extent:8 ; Medizinische Genetik ; 34, Heft 2 (2022), 117-124 (gesamt 8)

Contributors, Places and Time

• Creator: Morais, Vanessa A. ; Vos, Melissa

Further information

• DOI: 10.1515/medgen-2022-2138
• URN: urn:nbn:de:101:1-2022081214063953579914
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:25 AM CEST