Minimalist Design of Wireframe DNA Nanotubes: Tunable Geometry, Size, Chirality, and Dynamics
Abstract: DNA nanotubes (NTs) have attracted extensive interest as artificial cytoskeletons for biomedical, synthetic biology, and materials applications. Here, we report the modular design and assembly of a minimalist yet robust DNA wireframe nanotube with tunable cross‐sectional geometry, cavity size, chirality, and length, while using only four DNA strands. We introduce an h‐motif structure incorporating double‐crossover (DX) tile‐like DNA edges to achieve structural rigidity and provide efficient self‐assembly of h‐motif‐based DNA nanotube (H‐NT) units, thus producing programmable, micrometer‐long nanotubes. We demonstrate control of the H‐NT nanotube length via short DNA modulators. Finally, we use an enzyme, RNase H, to take these structures out of equilibrium and trigger nanotube assembly at a physiologically relevant temperature, underlining future cellular applications. The minimalist H‐NTs can assemble at near‐physiological salt conditions and will serve as an easily synthesized, DNA‐economical modular template for biosensors, plasmonics, or other functional materials and as cost‐efficient drug‐delivery vehicles for biomedical applications.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Minimalist Design of Wireframe DNA Nanotubes: Tunable Geometry, Size, Chirality, and Dynamics ; day:21 ; month:09 ; year:2023 ; extent:12
Angewandte Chemie / International edition. International edition ; (21.09.2023) (gesamt 12)
- Creator
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Luo, Xin
Saliba, Daniel
Yang, Tianxiao
Gentile, Serena
Mori, Keita
Islas, Patricia
Das, Trishalina
Bagheri, Neda
Porchetta, Alessandro
Guarne, Alba
Cosa, Gonzalo
Sleiman, Hanadi F.
- DOI
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10.1002/anie.202309869
- URN
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urn:nbn:de:101:1-2023092115120501208214
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:55 AM CEST
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Associated
- Luo, Xin
- Saliba, Daniel
- Yang, Tianxiao
- Gentile, Serena
- Mori, Keita
- Islas, Patricia
- Das, Trishalina
- Bagheri, Neda
- Porchetta, Alessandro
- Guarne, Alba
- Cosa, Gonzalo
- Sleiman, Hanadi F.
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