Wet‐Spinning of Biocompatible Core–Shell Polyelectrolyte Complex Fibers for Tissue Engineering
Abstract: Polyelectrolyte complex fibers (PEC fibers) have great potential with regard to biomedical applications as they can be fabricated from biocompatible and water‐soluble polyelectrolytes under mild process conditions. The present publication describes a novel method for the continuous fabrication of PEC fibers in a water‐based wet‐spinning process by interfacial complexation within a core–shell spinneret. This process combines the robustness and flexibility of nonsolvent‐induced phase separation (NIPS) spinning processes conventionally used in the membrane industry with the complexation between oppositely charged polyelectrolytes. The produced fibers demonstrate a core–shell structure with a low‐density core and a highly porous polyelectrolyte complex shell of ≈800 μm diameter. In the case of chitosan and polystyrene sulfonate (PSS), mechanical fiber properties could be enhanced by doping the PSS with poly (ethylene oxide) (PEO). The resulting CHI/PSS‐PEO fibers present a Young modulus of 3.78 GPa and a tensile strength of 165 MPa, which is an excellent combination of elongation at break and break stress compared to literature. The suitability of the CHI/PSS‐PEO fibers as a scaffold for cell culture applications is verified by a four‐day cultivation of human HeLa cells on PEO‐reinforced fibers with a subsequent analysis of cell viability by fluorescence‐based live/dead assay.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Wet‐Spinning of Biocompatible Core–Shell Polyelectrolyte Complex Fibers for Tissue Engineering ; volume:7 ; number:23 ; year:2020 ; extent:9
Advanced materials interfaces ; 7, Heft 23 (2020) (gesamt 9)
- Creator
- DOI
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10.1002/admi.202000849
- URN
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urn:nbn:de:101:1-2022052713511267163926
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:25 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Cui, Qing
- Bell, Daniel Josef
- Rauer, Sebastian Bernhard
- Wessling, Matthias
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Tailoring polyelectrolyte multilayer membranes for advanced selectivities
Ion transport in electrolyte and polyelectrolyte systems
Ion transport through electrolyte/polyelectrolyte multi-layers
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Wet spinning of core-shell and hollow polyelectrolyte fibers
Biocompatible Micron‐Scale Silk Fibers Fabricated by Microfluidic Wet Spinning
Fabrication of polyelectrolyte complex membranes
Biocompatible Micron‐Scale Silk Fibers Fabricated by Microfluidic Wet Spinning
Tailoring polyelectrolyte multilayer membranes for advanced selectivities
Ion transport in electrolyte and polyelectrolyte systems
Ion transport through electrolyte/polyelectrolyte multi-layers
Fiber spinning for tissue engineering applications
Wetting-Induced Polyelectrolyte Pore Bridging
Polyelectrolyte Complex Tubular Membranes via a Salt Dilution Induced Phase Inversion Process