Autocleaving Bonds for Better Drugs
Abstract: While bond formation has historically been the mainstay of medicinal chemistry, the phenomenon of bond cleavage has received less focus. However, the success of numerous oral medications demonstrates the importance of controlled cleavage in prodrugs to achieve desired therapeutic outcomes. Nevertheless, effective strategies to control this cleavage remain limited. This concept article introduces a novel approach: employing peptides as conjugates to drugs to modulate the hydrolysis of these conjugates and enhance drug efficacy. The article begins by briefly outlining common prodrug strategies, followed by a few representative examples of how peptides can be leveraged to control the autohydrolysis of peptide‐conjugated prodrugs for bacterial and cancer cell inhibition. Finally, it provides a brief outlook on the future potential of this promising new research direction in molecular medicine.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Autocleaving Bonds for Better Drugs ; day:29 ; month:04 ; year:2024 ; extent:7
ChemMedChem ; (29.04.2024) (gesamt 7)
- Creator
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Guo, Jiaqi
Chang, Annabelle
Xu, Bing
- DOI
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10.1002/cmdc.202400130
- URN
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urn:nbn:de:101:1-2404291446359.720997613541
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:44 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Guo, Jiaqi
- Chang, Annabelle
- Xu, Bing
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