The NFκB Signaling Pathway Is Involved in the Pathophysiological Process of Preeclampsia
Abstract: The high prevalence of preeclampsia (PE) is a major cause of maternal and fetal mortality and affects the long-term prognosis of both mother and baby. Termination of pregnancy is currently the only effective treatment for PE, so there is an urgent need for research into its pathogenesis and the development of new therapeutic approaches. The NFκB family of transcription factors has an essential role in inflammation and innate immunity. In this review, we summarize the role of NFκB in normal and preeclampsia pregnancies, the role of NFκB in existing treatment strategies, and potential NFκB treatment strategies.
Die hohe Prävalenz von Präeklampsie (PE) ist eine wesentliche Ursache mütterlicher und fetaler Mortalität und wirkt sich auch auf die Langzeitprognose von Mutter und Kind aus. Der Schwangerschaftsabbruch stellt zurzeit die einzig effektive Therapie gegen PE dar. Damit besteht ein dringender Bedarf nach weiterer Forschung zur Pathogenese von PE sowie zur Entwicklung neuer Therapieansätze. Die NFκB-Familie der Transkriptionsfaktoren spielt eine wichtige Rolle in Entzündungsprozessen und für die angeborene Immunität. In dieser Übersichtsstudie fassen wir die Rolle von NFκB bei normalen und Präeklampsie-Schwangerschaften sowie die Bedeutung von NFκB in bereits existierenden Therapien und potenzielle NFκB-Behandlungsstrategien zusammen.
- Alternative title
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Der NFκB-Signalweg ist am pathophysiologischen Prozess der Präeklampsie beteiligt
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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The NFκB Signaling Pathway Is Involved in the Pathophysiological Process of Preeclampsia ; volume:84 ; number:04 ; year:2024 ; pages:334-345
Geburtshilfe und Frauenheilkunde ; 84, Heft 04 (2024), 334-345
- Contributor
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Li, Yaxi
Zhu, Qinying
He, Ruifen
Du, Junhong
Qin, Xue
Li, Yi
Liang, Xiaolei
Wang, Jing
- DOI
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10.1055/a-2273-6318
- URN
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urn:nbn:de:101:1-2406060955508.055499463370
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:55 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Li, Yaxi
- Zhu, Qinying
- He, Ruifen
- Du, Junhong
- Qin, Xue
- Li, Yi
- Liang, Xiaolei
- Wang, Jing
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