A Strategy for the Formal C−N Cross‐Coupling of Tertiary Amines
Abstract: We report a strategy for the formal C−N cross‐coupling of tertiary amines via the in situ generation and displacement of N‐acyl ammonium species. Specifically, treatment of diverse tertiary amines with TFAA or chloroformates in the presence of NaI leads to the efficient generation of alkyl iodides, which can be engaged directly in Ni‐catalyzed cross‐couplings. The protocol is applicable to acyclic and cyclic systems, including highly hindered variants. Applications to the late‐stage modification of complex heterocycles are presented.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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A Strategy for the Formal C−N Cross‐Coupling of Tertiary Amines ; day:22 ; month:10 ; year:2024 ; extent:7
Angewandte Chemie / International edition. International edition ; (22.10.2024) (gesamt 7)
- Urheber
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Ledwith, Peter R.
Cooney, Madelene L.
Bahou, Karim A.
García‐Cárceles, Javier
Thomson, Joshua
Bower, John F.
- DOI
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10.1002/anie.202411555
- URN
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urn:nbn:de:101:1-2410231444133.798556684157
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:33 MESZ
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Beteiligte
- Ledwith, Peter R.
- Cooney, Madelene L.
- Bahou, Karim A.
- García‐Cárceles, Javier
- Thomson, Joshua
- Bower, John F.
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