US multicenter outcomes of endoscopic ultrasound-guided gallbladder drainage with lumen-apposing metal stents for acute cholecystitis

Background and study aims: EUS-guided gallbladder drainage (EUS-GBD) using lumen apposing metal stents (LAMS) has excellent technical and short-term clinical success for acute cholecystitis (AC). The goals of this study were to determine the long-term clinical outcomes and adverse events (AEs) of EUS-GBD with LAMS. Patients and methods: A multicenter, retrospective study was conducted at 18 US tertiary care institutions. Inclusion criteria: any AC patient with attempted EUS-GBD with LAMS and minimum 30-day post-procedure follow-up. Long-term clinical success was defined as absence of recurrent acute cholecystitis (RAC) > 30 days and long-term AE was defined as occurring > 30 days from the index procedure. Results: A total of 109 patients were included. Technical success was achieved in 108 of 109 (99.1%) and initial clinical success in 106 of 109 (97.2%). Long-term clinical success was achieved in 98 of 109 (89.9%) over a median follow-up of 140 days (range 30–1188). On multivariable analysis (MVA), acalculous cholecystitis (odds ratio [OR] 15.93, 95% confidence interval [CI] 1.22–208.52, P = 0.04) and the occurrence of a LAMS-specific AE (OR 63.60, 95% CI 5.08–799.29, P <0.01) were associated with RAC. AEs occurred in 38 of 109 patients (34.9%) at any time, and in 10 of 109 (9.17%) > 30 days from the index procedure. Most long-term AEs (7 of 109; 6.42%) were LAMS-specific. No technical or clinical factors were associated with occurrence of AEs. LAMS were removed in 24 of 109 patients (22%). There was no difference in RAC or AEs whether LAMS was removed or not. Conclusions: EUS-GBD with LAMS has a high rate of long-term clinical success and modest AE rates in patients with AC and is a reasonable destination therapy for high-risk surgical candidates.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: US multicenter outcomes of endoscopic ultrasound-guided gallbladder drainage with lumen-apposing metal stents for acute cholecystitis ; volume:13 ; number:CP ; year:2025 ; Endoscopy International Open ; 13, Heft CP (2025)

Contributors, Places and Time

• Contributor: David, Yakira ; Kakked, Gaurav ; Confer, Bradley ; Shah, Ruchit ; Khara, Harshit ; Diehl, David L. ; Krafft, Matthew Richard ; Shah-Khan, Sardar M. ; Nasr, John Y. ; Benias, Petros ; Trindade, Arvind ; Muniraj, Thiruvengadam ; Aslanian, Harry ; Chahal, Prabhleen ; Rodriguez, John ; Adler, Douglas G. ; Dubroff, Jason ; De Latour, Rabi ; Tzimas, Demetrios ; Khanna, Lauren ; Haber, Gregory ; Goodman, Adam J. ; Hoerter, Nicholas ; Pandey, Nishi ; Bakhit, Mena ; Kowalski, Thomas E. ; Loren, David ; Chiang, Austin ; Schlachterman, Alexander ; Nieto, Jose ; Deshmukh, Ameya ; Ichkhanian, Yervant ; Khashab, Mouen A. ; El Halabi, Maan ; Kwon, Richard S. ; Prabhu, Anoop ; Hernandez-Lara, Ariosto ; Storm, Andrew ; Berzin, Tyler M. ; Poneros, John ; Sethi, Amrita ; Gonda, Tamas A. ; Kushnir, Vladimir ; Cosgrove, Natalie ; Mullady, Daniel ; Al-Shahrani, Abdullah ; D'Souza, Lionel ; Buscaglia, Jonathan ; Bucobo, Juan Carlos ; Rolston, Vineet ; Kedia, Prashant ; Kasmin, Franklin ; Nagula, Satish ; Kumta, Nikhil A. ; DiMaio, Christopher

Further information

• DOI: 10.1055/a-2495-5542
• URN: urn:nbn:de:101:1-2503061124072.045434680299
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 2025-08-15T07:35:58+0200