Intestinal homeostasis and inflammation: Gut microbiota at the crossroads of pancreas–intestinal barrier axis

Abstract: The pancreas contains exocrine glands, which release enzymes (e.g., amylase, trypsin, and lipase) that are important for digestion and islets, which produce hormones. Digestive enzymes and hormones are secreted from the pancreas into the duodenum and bloodstream, respectively. Growing evidence suggests that the roles of the pancreas extend to not only the secretion of digestive enzymes and hormones but also to the regulation of intestinal homeostasis and inflammation (e.g., mucosal defense to pathogens and pathobionts). Organ crosstalk between the pancreas and intestine is linked to a range of physiological, immunological, and pathological activities, such as the regulation of the gut microbiota by the pancreatic proteins and lipids, the retroaction of the gut microbiota on the pancreas, the relationship between inflammatory bowel disease, and pancreatic diseases. We herein discuss the current understanding of the pancreas–intestinal barrier axis and the control of commensal bacteria in intestinal inflammation.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Intestinal homeostasis and inflammation: Gut microbiota at the crossroads of pancreas–intestinal barrier axis ; day:15 ; month:05 ; year:2022 ; extent:12 ; European journal of immunology ; (15.05.2022) (gesamt 12)

Contributors, Places and Time

• Creator: Zhang, Zhongwei ; Tanaka, Izumi ; Pan, Zhen ; Ernst, Peter B. ; Kiyono, Hiroshi ; Kurashima, Yosuke

Further information

• DOI: 10.1002/eji.202149532
• URN: urn:nbn:de:101:1-2022051615031436531346
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:32 AM CEST