Acute graft-versus-host disease, infections, vascular events and drug toxicities affecting the central nervous system
Abstract: Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative therapy for patients with hematological malignancies. Acute Graft versus host diseases (GVHD) is a major immune mediated side effect of allo-HCT that can affect the central nervous system (CNS) in addition to post-allo-HCT vascular events, drug toxicity or infections. Here we summarize and discuss recent preclinical data on the CNS as a target of acute GVHD and the known mechanisms contributing to neurotoxicity with a focus on microglia and T cells. We also discuss open questions in the field and place the findings made in mouse models in a clinical context. While in mice the neurological deficits can be assessed in a controlled fashion, in patients the etiology of the CNS damage is difficult to attribute to acute GVHD versus infections, vascular events, and drug-induced toxicity. Ultimately, we discuss novel therapies for GVHD of the CNS. Our understanding of the biological mechanisms that lead to neurotoxicity after allo-HCT increased over the last decade. This review provides insights into CNS manifestations of GVHD versus other etiologies of CNS damage in mice and patients
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
Frontiers in immunology. - 12 (2021) , 748019, ISSN: 1664-3224
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2021
- Creator
- DOI
-
10.3389/fimmu.2021.748019
- URN
-
urn:nbn:de:bsz:25-freidok-2220517
- Rights
-
Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:36 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Vinnakota, Janaki Manoja
- Zeiser, Robert
- Universität
Time of origin
- 2021
Other Objects (12)
Advances in understanding the pathogenesis of graft‐versus‐host disease
Immunomodulatory therapies for the treatment of graft-versus-host disease
Kinase inhibition as treatment for acute and chronic graft-versus-host disease
The role of purine metabolites as DAMPs in acute graft-versus-host disease
The role of MicroRNAs in myeloid cells during graft-versus-host disease
Die Rolle von extrazellulärem ATP bei der Entstehung der akuten Graft-©versus-©Host Erkrankung
Deciphering the role of the major histocompatibility complex, the intestinal microbiome and metabolites in the pathogenesis of acute graft-versus-host disease
Modulation of gastrointestinal graft-versus-host disease via the Enteroenedocrine glucagon-like peptide 2 (GLP-2)
Extracorporeal photopheresis in acute and chronic steroid‑refractory graft-versus-host disease: an evolving treatment landscape
Interfering with inflammation: heterogeneous effects of interferons in graft-versus-host disease of the gastrointestinal tract and inflammatory bowel disease
Editorial on translational research in graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) effect after allogeneic hematopoietic cell transplantation
Pathophysiology of gastrointestinal acute graft‐versus‐host disease and the potential role of glucagon‐like peptide 2
Advances in understanding the pathogenesis of graft‐versus‐host disease
Immunomodulatory therapies for the treatment of graft-versus-host disease
Kinase inhibition as treatment for acute and chronic graft-versus-host disease
The role of purine metabolites as DAMPs in acute graft-versus-host disease
The role of MicroRNAs in myeloid cells during graft-versus-host disease
Die Rolle von extrazellulärem ATP bei der Entstehung der akuten Graft-©versus-©Host Erkrankung
Deciphering the role of the major histocompatibility complex, the intestinal microbiome and metabolites in the pathogenesis of acute graft-versus-host disease
Modulation of gastrointestinal graft-versus-host disease via the Enteroenedocrine glucagon-like peptide 2 (GLP-2)
Extracorporeal photopheresis in acute and chronic steroid‑refractory graft-versus-host disease: an evolving treatment landscape
Interfering with inflammation: heterogeneous effects of interferons in graft-versus-host disease of the gastrointestinal tract and inflammatory bowel disease
Editorial on translational research in graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) effect after allogeneic hematopoietic cell transplantation
Pathophysiology of gastrointestinal acute graft‐versus‐host disease and the potential role of glucagon‐like peptide 2
Advances in understanding the pathogenesis of graft‐versus‐host disease
Immunomodulatory therapies for the treatment of graft-versus-host disease
Kinase inhibition as treatment for acute and chronic graft-versus-host disease
The role of purine metabolites as DAMPs in acute graft-versus-host disease
The role of MicroRNAs in myeloid cells during graft-versus-host disease
Die Rolle von extrazellulärem ATP bei der Entstehung der akuten Graft-©versus-©Host Erkrankung
Deciphering the role of the major histocompatibility complex, the intestinal microbiome and metabolites in the pathogenesis of acute graft-versus-host disease
Modulation of gastrointestinal graft-versus-host disease via the Enteroenedocrine glucagon-like peptide 2 (GLP-2)
Extracorporeal photopheresis in acute and chronic steroid‑refractory graft-versus-host disease: an evolving treatment landscape
Interfering with inflammation: heterogeneous effects of interferons in graft-versus-host disease of the gastrointestinal tract and inflammatory bowel disease
Editorial on translational research in graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) effect after allogeneic hematopoietic cell transplantation