Therapeutic application of PPE2 protein of Mycobacterium tuberculosis in inhibiting tissue inflammation
Abstract: There is an increasing need to develop biological anti‐inflammatory agents that are more targeted, effective, and with lesser side effects as compared to conventional chemical drugs. In the present study, we found that Mycobacterium tuberculosis protein PPE2 and a synthetic derivative peptide can suppress the mast cell population and inhibit several vasoactive and fibrogenic mediators and pro‐inflammatory cytokines induced by mast cells in formalin‐induced tissue injury. PPE2 was found to inhibit transcription from the promoter of stem cell factor, important for mast cell maintenance and migration. Thus, PPE2/peptide can be used as a potent nonsteroidal therapeutic agent for the treatment of inflammation and tissue injury.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Therapeutic application of PPE2 protein of Mycobacterium tuberculosis in inhibiting tissue inflammation ; day:11 ; month:07 ; year:2022 ; extent:28
EMBO molecular medicine / European Molecular Biology Organization ; (11.07.2022) (gesamt 28)
- Urheber
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Pal, Ravi
Battu, Madhu Babu
Mukhopadhyay, Sangita
- DOI
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10.15252/emmm.202114891
- URN
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urn:nbn:de:101:1-2022071115113675926938
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:30 MESZ
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Beteiligte
- Pal, Ravi
- Battu, Madhu Babu
- Mukhopadhyay, Sangita
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