d‐ Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection

Abstract: d‐Alanine, a rare d‐amino acid, exhibits a clear circadian rhythm and is present in organs associated with glucose metabolism. Recent findings have revealed that d‐alanine acts on the circadian rhythm, thereby regulating physiological processes related to circadian cycles that are essential for maintaining body homeostasis. The regulation of circadian rhythm by d‐alanine is vital for correcting blood glucose levels in diabetic conditions. In viral infections, d‐alanine serves as a sensitive biomarker that reflects the severity of the infection, as its level drastically decreases due to consumption. Supplementation with d‐alanine is effective to alleviate the progression of viral infections, potentially through the maintenance of the circadian rhythm and its associated immune responses. In addition to its role as a circadian biomarker, d‐alanine also functions as a circadian regulator and exerts a wide range of physiological effects. This review summarizes the physiological roles of d‐alanine as a circadian metabolite.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: d‐ Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection ; day:12 ; month:03 ; year:2025 ; extent:8 ; ChemBioChem ; (12.03.2025) (gesamt 8)

Contributors, Places and Time

• Creator: Kimura, Tomonori ; Sakai, Shinsuke ; Isaka, Yoshitaka

Further information

• DOI: 10.1002/cbic.202500018
• URN: urn:nbn:de:101:1-2503131322008.687216671307
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:29 AM CEST