Optogenetics 2.0: challenges and solutions towards a quantitative probing of neural circuits
Abstract: To exploit the full potential of optogenetics, we need to titrate and tailor optogenetic methods to emulate naturalistic circuit function. For that, the following prerequisites need to be met: first, we need to target opsin expression not only to genetically defined neurons per se, but to specifically target a functional node. Second, we need to assess the scope of optogenetic modulation, i.e. the fraction of optogenetically modulated neurons. Third, we need to integrate optogenetic control in a closed loop setting. Fourth, we need to further safe and stable gene expression and light delivery to bring optogenetics to the clinics. Here, we review these concepts for the human and rodent brain.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Optogenetics 2.0: challenges and solutions towards a quantitative probing of neural circuits ; volume:405 ; number:1 ; year:2024 ; pages:43-54 ; extent:12
Biological chemistry ; 405, Heft 1 (2024), 43-54 (gesamt 12)
- Urheber
- DOI
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10.1515/hsz-2023-0194
- URN
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urn:nbn:de:101:1-2023113013342531442580
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:32 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Altahini, Saleh
- Arnoux, Isabelle
- Stroh, Albrecht
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