A Review of Functional Neuroimaging in People with Down Syndrome with and without Dementia

Background: Individuals with Down syndrome (DS) are at high risk of dementia which is difficult to diagnose in DS. Neuroimaging has been identified as a potential tool to aid diagnosis by detecting changes in brain function. We carried out a review comparing functional neuroimaging in DS individuals with and without dementia. Summary: A literature search was conducted using PubMed to identify relevant studies. In DS subjects with dementia, fluorodeoxyglucose-positron emission tomography (PET) studies showed glucose hypometabolism particularly in the parietal and/or temporal regions whilst magnetic resonance spectroscopy studies showed increased myoinositol and decreased N-acetylaspartate. Ligand-based PET studies revealed significant Pittsburgh compound B binding in DS subjects over the age of 40, particularly if they had dementia. Key Messages: Neuroimaging may aid the early detection of dementia in DS; however, further longitudinal studies are required.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: A Review of Functional Neuroimaging in People with Down Syndrome with and without Dementia ; volume:11 ; number:3 ; year:2021 ; pages:324-332 ; extent:9 ; Dementia and geriatric cognitive disorders / Extra. Extra ; 11, Heft 3 (2021), 324-332 (gesamt 9)

Contributors, Places and Time

• Creator: Deinde, Funmi ; Kotecha, Jay ; Lau, Lilian Suh Lih ; Bhattacharyya, Sagnik ; Velayudhan, Latha

Further information

• DOI: 10.1159/000520880
• URN: urn:nbn:de:101:1-2022011223340583858757
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:30 AM CEST