Non‐Aqueous Phospholipid Concentrates for Increasing the Bioavailability of Poorly Soluble Compounds

Abstract: The properties and use of liquid non‐aqueous phospholipid concentrates (NAPC) are reviewed. They are mainly used to solubilize poorly water‐soluble drug substances to enhance their oral bioavailability, but they also find applicability in dietetics and cosmetics. Due to the large‐scale availability of these concentrates at good manufacturing practice quality including Drug Master File (DMF) documentation, they can be used for pre‐clinical screening and clinical testing and as market form, as demonstrated by the product of Wyeth/Pfizer, Rapamune, enabling a cost effective and fast dosage form development. When needed, NAPC can be converted to solid dosage forms by means of a capsule fill or addition of adsorbing excipients. It is concluded that NAPC deserve more attention and a broader use in the life science industry. Practical Applications: NAPCs are suitable as pre‐clinical formulation vehicle for screening of the oral bioavailability of poorly water‐soluble compounds. The same formulation can be used for clinical testing and market introduction, allowing a fast track dosage form development. When needed NAPC can be converted to solid dosage forms. NAPC have also applicability in dietetics and cosmetics to solubilize poorly water‐soluble compounds.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Non‐Aqueous Phospholipid Concentrates for Increasing the Bioavailability of Poorly Soluble Compounds ; volume:122 ; number:6 ; year:2020 ; extent:11 ; European journal of lipid science and technology ; 122, Heft 6 (2020) (gesamt 11)

Beteiligte, Orts- und Zeitangaben

• Urheber: van Hoogevest, Peter

Weitere Informationen

• DOI: 10.1002/ejlt.201900411
• URN: urn:nbn:de:101:1-2022063006325285791723
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:26 MESZ