Inflammatory caspases: key regulators of inflammation and cell death

Abstract: The innate immune system represents the first line of defence against infectious agents, and co-ordinates cellular and molecular mechanisms that result in effective inflammatory and anti-microbial responses against pathogens. Infection and cellular stress trigger assembly of canonical and noncanonical inflammasome complexes that activate the inflammatory caspases-1 and -11, respectively. These inflammatory caspases play key roles in innate immune responses by inducing pyroptosis to halt intracellular replication of pathogens, and by engaging the extracellular release of pro-inflammatory cytokines and danger signals. In addition, the inflammatory caspases-4, -5 and -11 were recently shown to directly bind microbial components. Although the immune roles of caspase-12 are debated, it was proposed to dampen inflammatory responses by interfering with caspase-1 activation and other innate immune pathways. Here, we recapitulate the reported roles of inflammatory caspases with an emphasis on recent insights into their biological functions.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Inflammatory caspases: key regulators of inflammation and cell death ; volume:396 ; number:3 ; year:2015 ; pages:193-203 ; extent:11 ; Biological chemistry ; 396, Heft 3 (2015), 193-203 (gesamt 11)

Contributors, Places and Time

• Creator: Jiménez-Fernández, Daniel ; Lamkanfi, Mohamed

Further information

• DOI: 10.1515/hsz-2014-0253
• URN: urn:nbn:de:101:1-2408051810215.970825982167
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:59 AM CEST