Infrared Diffusion‐Ordered Spectroscopy Reveals Molecular Size and Structure **

Abstract: Inspired by ideas from NMR, we have developed Infrared Diffusion‐Ordered Spectroscopy (IR‐DOSY), which simultaneously characterizes molecular structure and size. We rely on the fact that the diffusion coefficient of a molecule is determined by its size through the Stokes–Einstein relation, and achieve sensitivity to the diffusion coefficient by creating a concentration gradient and tracking its equilibration in an IR‐frequency resolved manner. Analogous to NMR‐DOSY, a two‐dimensional IR‐DOSY spectrum has IR frequency along one axis and diffusion coefficient (or equivalently, size) along the other, so the chemical structure and the size of a compound are characterized simultaneously. In an IR‐DOSY spectrum of a mixture, molecules with different sizes are nicely separated into distinct sets of IR peaks. Extending this idea to higher dimensions, we also perform 3D‐IR‐DOSY, in which we combine the conformation sensitivity of femtosecond multi‐dimensional IR spectroscopy with size sensitivity.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Infrared Diffusion‐Ordered Spectroscopy Reveals Molecular Size and Structure ** ; day:07 ; month:12 ; year:2022 ; extent:1 ; Angewandte Chemie / International edition. International edition ; (07.12.2022) (gesamt 1)

Contributors, Places and Time

• Creator: Giubertoni, Giulia ; Rombouts, Gijs ; Caporaletti, Federico ; Deblais, Antoine ; van Diest, Rianne ; Reek, Joost N. H. ; Bonn, Daniel ; Woutersen, Sander

Further information

• DOI: 10.1002/anie.202213424
• URN: urn:nbn:de:101:1-2022120815054301069161
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:36 AM CEST