Prostaglandin E2 production in synovial tissue and acute postoperative pain after knee arthroscopy

Methods: This is a clinical observational study of local inflammatory mediators and perceived pain in patients undergoing knee arthroscopy in general anesthesia with propofol, remifentanil and fentanyl. Microdialysis of the synovial membrane was performed in all patients every 20 min for 140 min postoperatively (seven samples). At the same intervals PGE2 was measured and correlated with patients report of pain intensity on a 0–100mm visual analogue scale (VAS). Results: Five patients (1 female, 4 male) who did not receive any non-steroidal antiinflammatory drugs or paracetamol were included. The pain intensity was 1–34mmVAS and the PGE2 levels were from 293 pg/ml to 5818 pg/ml. Maximum pain score (mean 23 and SD 12mm VAS) and PGE2 levels (mean 2026 pg/ml and SD 1380 pg/ml) occurred about 40 min after surgery. Correlation analysis shows a significant correlation (R = 0.48, p = 0.004). Conclusion: This pilot study indicates a positive correlation between postoperatively perceived pain and local PGE2 concentration.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Prostaglandin E2 production in synovial tissue and acute postoperative pain after knee arthroscopy ; volume:1 ; number:3 ; year:2010 ; pages:172-172 ; extent:1 ; Scandinavian journal of pain ; 1, Heft 3 (2010), 172-172 (gesamt 1)

Contributors, Places and Time

• Creator: Solheim, Nina ; Halvorsen, Bente ; Rosseland, Leiv Arne ; Stubhaug, Audun

Further information

• DOI: 10.1016/j.sjpain.2010.05.016
• URN: urn:nbn:de:101:1-2024022313463291072077
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:51 AM CEST