Pore formation in regulated cell death
Abstract: The discovery of alternative signaling pathways that regulate cell death has revealed multiple strategies for promoting cell death with diverse consequences at the tissue and organism level. Despite the divergence in the molecular components involved, membrane permeabilization is a common theme in the execution of regulated cell death. In apoptosis, the permeabilization of the outer mitochondrial membrane by BAX and BAK releases apoptotic factors that initiate the caspase cascade and is considered the point of no return in cell death commitment. Pyroptosis and necroptosis also require the perforation of the plasma membrane at the execution step, which involves Gasdermins in pyroptosis, and MLKL in the case of necroptosis. Although BAX/BAK, Gasdermins and MLKL share certain molecular features like oligomerization, they form pores in different cellular membranes via distinct mechanisms. Here, we compare and contrast how BAX/BAK, Gasdermins, and MLKL alter membrane permeability from a structural and biophysical perspective and discuss the general principles of membrane permeabilization in the execution of regulated cell death.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Pore formation in regulated cell death ; volume:39 ; number:23 ; year:2020 ; extent:18
The EMBO journal / European Molecular Biology Organization ; 39, Heft 23 (2020) (gesamt 18)
- Creator
- DOI
-
10.15252/embj.2020105753
- URN
-
urn:nbn:de:101:1-2022062707513405380905
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:25 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Flores‐Romero, Hector
- Ros, Uris
- García-Sáez, Ana J.
Other Objects (12)
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
Lipid signaling in regulated necrotic cell death
Inhibition of regulated cell death by cell-penetrating peptides
Necroptosis: a regulated inflammatory mode of cell death
Mitochondrial origins of fractional control in regulated cell death
Sperm freezing damage: the role of regulated cell death
Regulated cell death in the pathogenesis of renal ciliopathies
Dysregulated dendritic cells in sepsis: functional impairment and regulated cell death
Kremen1-induced cell death is regulated by homo- and heterodimerization
Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections
Regulated cell death: discovery, features and implications for neurodegenerative diseases
Mitophagy-related regulated cell death: molecular mechanisms and disease implications
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
Lipid signaling in regulated necrotic cell death
Inhibition of regulated cell death by cell-penetrating peptides
Necroptosis: a regulated inflammatory mode of cell death
Mitochondrial origins of fractional control in regulated cell death
Sperm freezing damage: the role of regulated cell death
Regulated cell death in the pathogenesis of renal ciliopathies
Dysregulated dendritic cells in sepsis: functional impairment and regulated cell death
Kremen1-induced cell death is regulated by homo- and heterodimerization
Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections
Regulated cell death: discovery, features and implications for neurodegenerative diseases
Mitophagy-related regulated cell death: molecular mechanisms and disease implications
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
Lipid signaling in regulated necrotic cell death
Inhibition of regulated cell death by cell-penetrating peptides
Necroptosis: a regulated inflammatory mode of cell death
Mitochondrial origins of fractional control in regulated cell death
Sperm freezing damage: the role of regulated cell death
Regulated cell death in the pathogenesis of renal ciliopathies
Dysregulated dendritic cells in sepsis: functional impairment and regulated cell death
Kremen1-induced cell death is regulated by homo- and heterodimerization
Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections
Regulated cell death: discovery, features and implications for neurodegenerative diseases