Transcellular Spreading of Tau in Tauopathies
Abstract: Tau, a microtubule‐associated protein playing a key role in a group of neurodegenerative diseases such as Alzheimer's disease, spreads throughout the brain, inducing pathology. A model akin to the spreading of prions has been raised owing to similar characteristics of inducing an abnormal protein conformation as a method of self‐amplification, spreading protein aggregates over anatomically linked pathways. The search to identify the “seeds” that induce conformational change has received much attention; however, less is known about the mechanisms by which tau is transmitted from cell to cell, so‐called “transcellular spreading”. In this review, we gather evidence regarding the spreading of tau throughout the brain and provide an overview of methods by which tau can be released from neurons as well as taken up. Furthermore, we bring together mechanisms of neurotoxicity behind tau spreading. Advancing our understanding about the spreading of tau can guide the search for therapeutic options for multiple neurodegenerative diseases aggregating tau.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Transcellular Spreading of Tau in Tauopathies ; volume:19 ; number:23 ; year:2018 ; pages:2424-2432 ; extent:9
ChemBioChem ; 19, Heft 23 (2018), 2424-2432 (gesamt 9)
- Creator
- DOI
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10.1002/cbic.201800288
- URN
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urn:nbn:de:101:1-2022082308261748539077
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:27 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Demaegd, Koen
- Schymkowitz, Joost
- Rousseau, Frederic
Other Objects (12)
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Spreading of Tau Protein Does Not Depend on Aggregation Propensity
Sorting, missorting and spreading of Tau in neurons studied in microfluidic chambers
Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau
Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
Mechanisms of pathogenic tau and A[Beta] protein spreading in Alzheimer’s disease
Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain
Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading
Exploring modulators of tau spreading in Alzheimer’s disease through multi-modal neuroimaging biomarkers
Mechanisms of secretion and spreading of pathological tau protein
BIN1 favors the spreading of Tau via extracellular vesicles
Relationship between amyloid and tau levels and its impact on tau spreading
Spreading of Tau Protein Does Not Depend on Aggregation Propensity
Sorting, missorting and spreading of Tau in neurons studied in microfluidic chambers
Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau
Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
Mechanisms of pathogenic tau and A[Beta] protein spreading in Alzheimer’s disease
Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain
Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading
Exploring modulators of tau spreading in Alzheimer’s disease through multi-modal neuroimaging biomarkers
Mechanisms of secretion and spreading of pathological tau protein
BIN1 favors the spreading of Tau via extracellular vesicles
Relationship between amyloid and tau levels and its impact on tau spreading
Spreading of Tau Protein Does Not Depend on Aggregation Propensity
Sorting, missorting and spreading of Tau in neurons studied in microfluidic chambers
Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau
Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
Mechanisms of pathogenic tau and A[Beta] protein spreading in Alzheimer’s disease
Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain
Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading