On the Helical Crystals of Cholesterol Monohydrate
Abstract: We review in this short perspective the history of cholesterol crystals and crystal structures. We address in particular the helical crystals that form in vitro and in pathology from environments rich in bile acids or from phospholipid membranes. We review the known mechanisms leading to crystals with chiral morphology, from screw‐dislocation mediated growth to mechanisms involving asymmetric mechanical strain. We propose a mechanism for cholesterol helical crystal development based on the monoclinic cholesterol monohydrate crystal structure. We suggest that curvature arises in few layers thick crystals due to the tension induced between the hydrophobic layer and the ice‐like H‐bonded lattice of the water molecules with the cholesterol hydroxy groups. Helicity would ensue through a combination of the curvature and the fast growth of a thin ribbon in one crystal direction.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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On the Helical Crystals of Cholesterol Monohydrate ; day:01 ; month:03 ; year:2023 ; extent:10
Helvetica chimica acta ; (01.03.2023) (gesamt 10)
- Creator
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Addadi, Lia
Varsano, Neta
Ben Moshe, Assaf
- DOI
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10.1002/hlca.202200173
- URN
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urn:nbn:de:101:1-2023030114272862490109
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:00 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Addadi, Lia
- Varsano, Neta
- Ben Moshe, Assaf
Other Objects (12)
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Crystal structure of disodium praseodymium pentanitrate monohydrate, Na2[Pr(NO3)5] H2O
Helical Bloch Modes in Twisted Photonic Crystal Fibers
Crystal structure of tetraaqua gadolinium trinitrate monohydrate, [Gd(NO3)3(H2O)4] H2O
Crystal structure of tetraaqua gadolinium trinitrate monohydrate, [Gd(NO3)3(H2O)4] H2O
Diminutive Gastrointestinal Lesions in Cholesterol Crystal Embolization
Metabolic comorbidities modulate kidney cholesterol crystal embolism
Targeting cholesterol crystals in atherosclerosis with cholesterol solubilizing 2-hydroxypropyl-beta-cyclodextrin
Changing Liquid Crystal Helical Pitch with a Reversible Rotaxane Switch
In situ Growth Transition Towards Helical Crystals of Achiral Molecules
Crystal structure of sparteinium tetrachlorocuprate monohydrate-packing polymorph
Impact of cholesterol and Lumacaftor on the folding of CFTR helical hairpins
Phononic angular dispersion of the triclinic crystal lithium hydrogen oxalate monohydrate
Crystal structure of disodium praseodymium pentanitrate monohydrate, Na2[Pr(NO3)5] H2O
Helical Bloch Modes in Twisted Photonic Crystal Fibers
Crystal structure of tetraaqua gadolinium trinitrate monohydrate, [Gd(NO3)3(H2O)4] H2O
Crystal structure of tetraaqua gadolinium trinitrate monohydrate, [Gd(NO3)3(H2O)4] H2O
Diminutive Gastrointestinal Lesions in Cholesterol Crystal Embolization
Metabolic comorbidities modulate kidney cholesterol crystal embolism
Targeting cholesterol crystals in atherosclerosis with cholesterol solubilizing 2-hydroxypropyl-beta-cyclodextrin
Changing Liquid Crystal Helical Pitch with a Reversible Rotaxane Switch
In situ Growth Transition Towards Helical Crystals of Achiral Molecules
Crystal structure of sparteinium tetrachlorocuprate monohydrate-packing polymorph
Impact of cholesterol and Lumacaftor on the folding of CFTR helical hairpins
Phononic angular dispersion of the triclinic crystal lithium hydrogen oxalate monohydrate
Crystal structure of disodium praseodymium pentanitrate monohydrate, Na2[Pr(NO3)5] H2O
Helical Bloch Modes in Twisted Photonic Crystal Fibers
Crystal structure of tetraaqua gadolinium trinitrate monohydrate, [Gd(NO3)3(H2O)4] H2O
Crystal structure of tetraaqua gadolinium trinitrate monohydrate, [Gd(NO3)3(H2O)4] H2O
Diminutive Gastrointestinal Lesions in Cholesterol Crystal Embolization
Metabolic comorbidities modulate kidney cholesterol crystal embolism
Targeting cholesterol crystals in atherosclerosis with cholesterol solubilizing 2-hydroxypropyl-beta-cyclodextrin
Changing Liquid Crystal Helical Pitch with a Reversible Rotaxane Switch