Malignant Gastrointestinal Stromal Tumor of Rectum: A Case Report and Review of Literature

Abstract: Gastrointestinal stromal tumors (GISTs) are rare tumors of the gastrointestinal tract accounting for less than 1% of all gut tumors. GISTs occurring in the rectum are extremely rare and these usually present at an advanced stage compared with other sites. We report a case of a middle-aged female who presented with features of anemia and subacute obstruction due to a large rectal tumor and underwent abdominoperineal resection. The histopathological examination confirmed the diagnosis of high-grade malignant GIST with multiple lymph nodal metastasis. She was started on adjuvant imatinib therapy and is on follow-up without any evidence of recurrence. The authors conclude that GIST must be included in the differential diagnosis of a rectal tumor. Diagnosis is established by biopsy and immunohistochemistry studies. Surgical resection with histological negative margins is the standard curative treatment. Adjuvant targeted therapy can reduce long-term recurrence in high-risk cases.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Malignant Gastrointestinal Stromal Tumor of Rectum: A Case Report and Review of Literature ; volume:08 ; number:01 ; year:2022 ; pages:e60-e64 ; The surgery journal ; 08, Heft 01 (2022), e60-e64

Contributors, Places and Time

• Contributor: Karthikeyan, Mohan ; Kolandasamy, Chinnusamy ; Naganath Babu, Obla L.

Further information

• DOI: 10.1055/s-0042-1742778
• URN: urn:nbn:de:101:1-2022041410331982849714
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:25 AM CEST