Recognition‐Encoded Molecules: A Minimal Self‐Replicator

Abstract: Nucleic acids, with their unique duplex structure, which is key for information replication, have sparked interest in self‐replication's role in life's origins. Early template‐based replicators, initially built on short oligonucleotides, expanded to include peptides and synthetic molecules. We explore here the potential of a class of synthetic duplex‐forming oligoanilines, as self‐replicators. We have recently developed oligoanilines equipped with 2‐trifluoromethylphenol–phosphine oxide H‐bond base pairs and we investigate whether the imine formed between aniline and aldehyde complementary monomers can self‐replicate. Despite lacking a clear sigmoidal kinetic profile, control experiments with a methylated donor and a competitive inhibitor support self‐replication. Further investigations with the reduced aniline dimer demonstrate templated synthesis, revealing a characteristic parabolic growth. After showing sequence selective duplex formation, templated synthesis and the emergence of catalytic function, the self‐replication behaviour further suggests that the unique properties of nucleic acids can be paralleled by synthetic recognition‐encoded molecules.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Recognition‐Encoded Molecules: A Minimal Self‐Replicator ; day:31 ; month:10 ; year:2024 ; extent:7 ; Chemistry - a European journal ; (31.10.2024) (gesamt 7)

Contributors, Places and Time

• Creator: Rosa‐Gastaldo, Daniele ; Maria Ara, Francesco ; Dalla Valle, Andrea ; Visentin, Giulia ; Gabrielli, Luca

Further information

• DOI: 10.1002/chem.202401667
• URN: urn:nbn:de:101:1-2410311341479.414039875924
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:21 AM CEST