A genome-wide association study of marginal zone lymphoma shows association to the HLA region
Abstract: Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10−15) and HLA-B (rs2922994, P=2.43 × 10−9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Nature communications. - 6 (2015) , 5751, ISSN: 2041-1723
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2021
- Urheber
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Vijai, Joseph
Wu, Xifeng
Cerhan, James R.
Offit, Kenneth
Chanock, Stephen J.
Rothman, Nathaniel
Nieters, Alexandra
- DOI
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10.1038/ncomms6751
- URN
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urn:nbn:de:bsz:25-freidok-1935975
- Rechteinformation
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Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:56 MEZ
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Beteiligte
- Vijai, Joseph
- Wu, Xifeng
- Cerhan, James R.
- Offit, Kenneth
- Chanock, Stephen J.
- Rothman, Nathaniel
- Nieters, Alexandra
- Universität
Entstanden
- 2021
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