Fractionation of a Three‐Particle Mixture by Brownian Sieving Hydrodynamic Chromatography
Abstract: Particles ranging in size from a few nanometers (exosomes or viruses) to a few micrometers (bacteria or red blood cells) can be sorted using a size‐based separation process. One of the simplest techniques is provided by hydrodynamic chromatography (HDC) which typically requires long channels to achieve adequate resolution. A new separation mechanism based on a Brownian sieving effect coupled with HDC has recently been proposed to overcome these limitations. An efficiency improvement of up to 2000 % has been predicted for a two‐size mixture. The aim of this work is to study and optimize a modified geometry useful for obtaining the simultaneous separation of a three‐size diluted suspension. The results suggest a significant performance improvement, up to 3000 %, over the standard HDC.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Fractionation of a Three‐Particle Mixture by Brownian Sieving Hydrodynamic Chromatography ; day:01 ; month:03 ; year:2023 ; extent:8
Chemical engineering & technology ; (01.03.2023) (gesamt 8)
- Creator
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Biagioni, Valentina
Venditti, Claudia
Adrover, Alessandra
Cerbelli, Stefano
- DOI
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10.1002/ceat.202200490
- URN
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urn:nbn:de:101:1-2023030114290241684971
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:01 AM CEST
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Associated
- Biagioni, Valentina
- Venditti, Claudia
- Adrover, Alessandra
- Cerbelli, Stefano
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