Synthesis and AChE inhibitory activity of N -glycosyl benzofuran derivatives
Abstract: Six N-glycosyl benzofuran derivatives were synthesized by the catalysis of organic bases and condensation agents. The benzofuran derivatives were obtained by the reaction of various salicylaldehydes in acetone, and then hydrolyzed to the corresponding carboxylic acids. Finally, the target compounds were synthesized by acylation and the reaction conditions were optimized. The acetylcholinesterase (AChE) inhibitory activity of the desired compounds was tested using Ellman’s method. Most of the compounds showed acetylcholinesterase-inhibition activity; N-(2,4,5-trihydroxy-6-(hydroxymethyl) tetrahydro-2H-pyran-3-yl) benzofuran-2-carbxamide (5a) showed the best acetylcholinesterase inhibition, with an inhibitory rate of 84%.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Synthesis and AChE inhibitory activity of N -glycosyl benzofuran derivatives ; volume:25 ; number:1 ; year:2019 ; pages:162-166 ; extent:5
Heterocyclic communications ; 25, Heft 1 (2019), 162-166 (gesamt 5)
- Creator
-
Wu, Yu-Ran
Ren, Shu-Ting
Wang, Lei
Liu, Xiu-Jian
Wang, You-Xian
Liu, Shu-Hao
Liu, Wei-Wei
Shi, Da-Hua
Cao, Zhi-Ling
- DOI
-
10.1515/hc-2019-0021
- URN
-
urn:nbn:de:101:1-2501140306230.158424151175
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:35 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wu, Yu-Ran
- Ren, Shu-Ting
- Wang, Lei
- Liu, Xiu-Jian
- Wang, You-Xian
- Liu, Shu-Hao
- Liu, Wei-Wei
- Shi, Da-Hua
- Cao, Zhi-Ling
Other Objects (12)
Synthesis and bioactivity of novel C2-glycosyl triazole derivatives as acetylcholinesterase inhibitors
Game Playing in the Platform Society: A Cultural-Political Economy Analysis of the Live Streaming Industry in China
Synthesis and bioactivity of novel C2-glycosyl oxadiazole derivatives as acetylcholinesterase inhibitors
Specification and collaboration driven software component selection : building a framework for component selection
On beyond-birthday-bound security: revisiting the development of ISO/IEC 9797-1 MACs
Improved electrical coupling integrated energy system based on particle swarm optimization
A treecode based on barycentric Hermite interpolation for electrostatic particle interactions
Tania Kuteva, Bernd Heine, Bo Hong, Haiping Long, Heiko Narrog and Seongha Rhee: World lexicon of grammaticalization
High‐Throughput Inertial Focusing of Micrometer‐ and Sub‐Micrometer‐Sized Particles Separation
Inflation, electroweak phase transition, and Higgs searches at the LHC in the two-Higgs-doublet model
Adenovirus-Mediated Expression of BMP-2 and BFGF in Bone Marrow Mesenchymal Stem Cells Combined with Demineralized Bone Matrix For Repair of Femoral Head Osteonecrosis in Beagle Dogs
Valorization of Protein Materials Through Mechanochemistry and Self‐Assembly
Synthesis and bioactivity of novel C2-glycosyl triazole derivatives as acetylcholinesterase inhibitors
Game Playing in the Platform Society: A Cultural-Political Economy Analysis of the Live Streaming Industry in China
Synthesis and bioactivity of novel C2-glycosyl oxadiazole derivatives as acetylcholinesterase inhibitors
Specification and collaboration driven software component selection : building a framework for component selection
On beyond-birthday-bound security: revisiting the development of ISO/IEC 9797-1 MACs
Improved electrical coupling integrated energy system based on particle swarm optimization
A treecode based on barycentric Hermite interpolation for electrostatic particle interactions
Tania Kuteva, Bernd Heine, Bo Hong, Haiping Long, Heiko Narrog and Seongha Rhee: World lexicon of grammaticalization
High‐Throughput Inertial Focusing of Micrometer‐ and Sub‐Micrometer‐Sized Particles Separation
Inflation, electroweak phase transition, and Higgs searches at the LHC in the two-Higgs-doublet model
Adenovirus-Mediated Expression of BMP-2 and BFGF in Bone Marrow Mesenchymal Stem Cells Combined with Demineralized Bone Matrix For Repair of Femoral Head Osteonecrosis in Beagle Dogs
Valorization of Protein Materials Through Mechanochemistry and Self‐Assembly
Synthesis and bioactivity of novel C2-glycosyl triazole derivatives as acetylcholinesterase inhibitors
Game Playing in the Platform Society: A Cultural-Political Economy Analysis of the Live Streaming Industry in China
Synthesis and bioactivity of novel C2-glycosyl oxadiazole derivatives as acetylcholinesterase inhibitors
Specification and collaboration driven software component selection : building a framework for component selection
On beyond-birthday-bound security: revisiting the development of ISO/IEC 9797-1 MACs
Improved electrical coupling integrated energy system based on particle swarm optimization
A treecode based on barycentric Hermite interpolation for electrostatic particle interactions
Tania Kuteva, Bernd Heine, Bo Hong, Haiping Long, Heiko Narrog and Seongha Rhee: World lexicon of grammaticalization
High‐Throughput Inertial Focusing of Micrometer‐ and Sub‐Micrometer‐Sized Particles Separation
Inflation, electroweak phase transition, and Higgs searches at the LHC in the two-Higgs-doublet model
Adenovirus-Mediated Expression of BMP-2 and BFGF in Bone Marrow Mesenchymal Stem Cells Combined with Demineralized Bone Matrix For Repair of Femoral Head Osteonecrosis in Beagle Dogs