Oncogenic transgelin-2 is differentially regulated in isocitrate dehydrogenase wild-type vs. mutant gliomas
Abstract: The presence of an isocitrate dehydrogenase (IDH1/2) mutation in gliomas is associated with favorable outcomes compared to gliomas without the mutation (IDH1/2 wild-type, WT). The underlying biological mechanisms accounting for improved clinical outcomes in IDH1/2 mutant gliomas remain poorly understood, but may, in part, be due to the glioma CpG island methylator phenotype (G-CIMP) and epigenetic silencing of genes. We performed profiling of IDH1/2 WT versus IDH1/2 mutant Grade II and III gliomas and identified transgelin-2 (TAGLN2), an oncogene and actin-polymerizing protein, to be expressed at significantly higher levels in IDH1/2 WT gliomas compared to IDH1/2 mutant gliomas. This differential expression of TAGLN2 was primarily due to promoter hypermethylation in IDH1/2 mutant gliomas, suggesting involvement of TAGLN2 in the G-CIMP. Our results also suggest that TAGLN2 may be involved in progression due to higher expression in glioblastomas compared to IDH1/2 WT gliomas of lower grades. Furthermore, our results suggest that TAGLN2 functions as an oncogene by contributing to proliferation and invasion when overexpressed in IDH1/2 WT glioma cells. Taken together, this study demonstrates a possible link between increased TAGLN2 expression, invasion and poor patient outcomes in IDH1/2 WT gliomas and identifies TAGLN2 as a potential novel therapeutic target for IDH1/2 WT gliomas
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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OncoTarget. - 9 (2018) , 37097-37111, ISSN: 1949-2553
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2023
- Creator
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Beyer, Sasha J.
Bell, Erica Hlavin
McElroy, Joseph P.
Fleming, Jessica L.
Cui, Tiantian
Becker, Aline P.
Bassett, Emily
Johnson, Benjamin
Gulati, Pooja
Popp, Ilinca
Staszewski, Ori
Prinz, Marco
Grosu, Anca-Ligia
Haque, Saikh Jaharul
Chakravarti, Arnab
- DOI
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10.18632/oncotarget.26365
- URN
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urn:nbn:de:bsz:25-freidok-1489987
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:49 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Beyer, Sasha J.
- Bell, Erica Hlavin
- McElroy, Joseph P.
- Fleming, Jessica L.
- Cui, Tiantian
- Becker, Aline P.
- Bassett, Emily
- Johnson, Benjamin
- Gulati, Pooja
- Popp, Ilinca
- Staszewski, Ori
- Prinz, Marco
- Grosu, Anca-Ligia
- Haque, Saikh Jaharul
- Chakravarti, Arnab
- Universität
Time of origin
- 2023
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