ATP Drives the Formation of a Catalytic Hydrazone through an Energy Ratchet Mechanism

Abstract: An energy ratchet mechanism is exploited for the synthesis of a molecule. In the presence of adenosine triphosphate (ATP), hydrazone‐bond formation between an aldehyde and hydrazide is accelerated and the composition at thermodynamic equilibrium is shifted towards the hydrazone. Enzymatic hydrolysis of ATP installs a kinetically stable state, at which hydrazone is present at a higher concentration compared to the composition at thermodynamic equilibrium in the presence of the degradation products of ATP. It is shown that the kinetic state has an enhanced catalytic activity in the hydrolysis of an RNA‐model compound.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: ATP Drives the Formation of a Catalytic Hydrazone through an Energy Ratchet Mechanism ; day:10 ; month:07 ; year:2023 ; extent:6 ; Angewandte Chemie / International edition. International edition ; (10.07.2023) (gesamt 6)

Beteiligte, Orts- und Zeitangaben

• Urheber: Marchetti, Tommaso ; Frezzato, Diego ; Gabrielli, Luca ; Prins, Leonard J.

Weitere Informationen

• DOI: 10.1002/anie.202307530
• URN: urn:nbn:de:101:1-2023071115252466526144
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:57 MESZ