New Designs for Phototherapeutic Transition Metal Complexes

Abstract: In this Minireview, we highlight recent advances in the design of transition metal complexes for photodynamic therapy (PDT) and photoactivated chemotherapy (PACT), and discuss the challenges and opportunities for the translation of such agents into clinical use. New designs for light‐activated transition metal complexes offer photoactivatable prodrugs with novel targeted mechanisms of action. Light irradiation can provide spatial and temporal control of drug activation, increasing selectivity and reducing side‐effects. The photophysical and photochemical properties of transition metal complexes can be controlled by the appropriate choice of the metal, its oxidation state, the number and types of ligands, and the coordination geometry.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: New Designs for Phototherapeutic Transition Metal Complexes ; volume:132 ; number:1 ; year:2020 ; pages:61-73 ; extent:13 ; Angewandte Chemie ; 132, Heft 1 (2020), 61-73 (gesamt 13)

Beteiligte, Orts- und Zeitangaben

• Urheber: Imberti, Cinzia ; Zhang, Pingyu ; Huang, Huaiyi ; Sadler, Peter J.

Weitere Informationen

• DOI: 10.1002/ange.201905171
• URN: urn:nbn:de:101:1-2022052511200069988902
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:38 MESZ