Proteasome activity in experimental diabetes
Abstract: Numerous studies have indicated that oxidative stress contributes to the development and progression of diabetes and other related complications. Since the ubiquitin-proteasome pathway is involved in degradation of oxidized proteins, it is to be expected that alterations in proteasome-dependent proteolysis accompany diabetes. This paper focuses on the role of the proteasome in alloxan-induced experimental diabetes. The changes in proteasomal activity and oxidative stress indices (protein oxidation and lipid peroxidation) were evaluated. The obtained results revealed increased protein oxidation and lipid peroxidation, as well as alterations in proteasomal activities in diabetic rats. Our data indicates a significant decrease in chymotryptic-like activity; increased tryptic-like activity; and unchanged post-glutamyl peptide hydrolytic-like activity. These findings suggest the presence of oxidative stress in diabetes that appears to result in changes to the ubiquitin-proteasome pathway.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Proteasome activity in experimental diabetes ; volume:1 ; number:2 ; year:2006 ; pages:289-298 ; extent:10
Open life sciences ; 1, Heft 2 (2006), 289-298 (gesamt 10)
- Creator
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Alexandrova, Albena
Petrov, Lubomir
Kirkova, Margarita
- DOI
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10.2478/s11535-006-0017-3
- URN
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urn:nbn:de:101:1-2409201716077.240169727833
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:35 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Alexandrova, Albena
- Petrov, Lubomir
- Kirkova, Margarita
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