Remotely Controlled Electrochemical Degradation of Metallic Implants
Abstract: Biodegradable medical implants promise to benefit patients by eliminating risks and discomfort associated with permanent implantation or surgical removal. The time until full resorption is largely determined by the implant's material composition, geometric design, and surface properties. Implants with a fixed residence time, however, cannot account for the needs of individual patients, thereby imposing limits on personalization. Here, an active Fe‐based implant system is reported whose biodegradation is controlled remotely and in situ. This is achieved by incorporating a galvanic cell within the implant. An external and wireless signal is used to activate the on‐board electronic circuit that controls the corrosion current between the implant body and an integrated counter electrode. This configuration leads to the accelerated degradation of the implant and allows to harvest electrochemical energy that is naturally released by corrosion. In this study, the electrochemical properties of the Fe‐30Mn‐1C/Pt galvanic cell model system is first investigated and high‐resolution X‐ray microcomputed tomography is used to evaluate the galvanic degradation of stent structures. Subsequently, a centimeter‐sized active implant prototype is assembled with conventional electronic components and the remotely controlled corrosion is tested in vitro. Furthermore, strategies toward the miniaturization and full biodegradability of this system are presented.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Remotely Controlled Electrochemical Degradation of Metallic Implants ; day:07 ; month:02 ; year:2024 ; extent:14
Small ; (07.02.2024) (gesamt 14)
- Creator
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Rivkin, Boris
Akbar, Farzin
Otto, Martin
Beyer, Lukas
Paul, Birgit
Kosiba, Konrad
Gustmann, Tobias
Hufenbach, Julia Kristin
Medina‐Sánchez, Mariana
- DOI
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10.1002/smll.202307742
- URN
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urn:nbn:de:101:1-2024020814132812627943
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:23 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Rivkin, Boris
- Akbar, Farzin
- Otto, Martin
- Beyer, Lukas
- Paul, Birgit
- Kosiba, Konrad
- Gustmann, Tobias
- Hufenbach, Julia Kristin
- Medina‐Sánchez, Mariana
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Optimizing alkaline hydrothermal treatment for biomimetic smart metallic orthopedic and dental implants
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Potential-induced nanoclustering of metallic catalysts during electrochemical CO2 reduction
Laser-patterned metallic interconnections for all stretchable organic electrochemical transistors
Electrochemical hydrogen absorption by Zr-Cu-Al-Ni metallic glasses
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Retention of Metallic and Non-Metallic Double Crown-Retained Overdentures on Implants
Nitric oxide-generating metallic wires for enhanced metal implants
Electrochemical modulation and restructuring of planar metallic metamaterials
Optimizing alkaline hydrothermal treatment for biomimetic smart metallic orthopedic and dental implants
Electrochemical hydrogen absorption by Zr-Cu-Al-Ni metallic glasses
Potential-induced nanoclustering of metallic catalysts during electrochemical CO2 reduction
Laser-patterned metallic interconnections for all stretchable organic electrochemical transistors
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