Active surveillance for low-grade appendiceal mucinous neoplasm (LAMN)

Objectives: Due to the scarcity of low-grade appendiceal mucinous neoplasm (LAMN), there is an absence of systematized guidelines concerning its management, especially after incidental finding on an appendiceal specimen. In this study, we evaluate the active surveillance (AS) strategy adopted for a series of patients diagnosed with LAMN on resection specimens who were considered to have a low risk of pseudomyxoma progression. Methods: Thirty patients were included between April 2014 and July 2021, with a female majority and a median follow-up period of 3.1 years. The inclusion criteria were as follows: LAMN diagnosis on appendiceal specimens, confirmed in an expert center, limited extra-appendiceal mucin resected and localized around the appendix, normal biology (CEA, CA199, CA125) and normal abdominopelvic MRI. AS included physical exam (trocar scar), biology and MRI, 6 months postoperatively, then yearly for 10 years. Results: As an initial surgery, 77 % had an appendectomy as their initial intervention, 17 % had a cecectomy, and 6 % had a right colectomy. After follow-up, 87 % of patients showed no sign of disease progression by MRI, while 13 % progressed to PMP. MRI performed in the first postoperative year predicted the disease prognosis in 97 % of patients. Conclusions: The AS strategy, based on MRI, is a valid option after incidental LAMN diagnosis.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Active surveillance for low-grade appendiceal mucinous neoplasm (LAMN) ; volume:9 ; number:1 ; year:2023 ; pages:31-37 ; extent:07 ; Pleura and peritoneum ; 9, Heft 1 (2023), 31-37 (gesamt 07)

Beteiligte, Orts- und Zeitangaben

• Urheber: Mouawad, Christian ; Bardier, Armelle ; Wagner, Mathilde ; Doat, Solène ; Djelil, Dahbia ; Fawaz, Jade ; Pocard, Marc

Weitere Informationen

• DOI: 10.1515/pp-2023-0032
• URN: urn:nbn:de:101:1-2024033014360376622439
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 11:02 MESZ