Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects
Abstract: While new biomaterials for regenerative therapies are being reported in the literature, clinical translation is slow. Some existing regenerative approaches rely on high doses of growth factors, such as bone morphogenetic protein‐2 (BMP‐2) in bone regeneration, which can cause serious side effects. An ultralow‐dose growth factor technology is described yielding high bioactivity based on a simple polymer, poly (ethyl acrylate) (PEA), and mechanisms to drive stem cell differentiation and bone regeneration in a critical‐sized murine defect model with translation to a clinical veterinary setting are reported. This material‐based technology triggers spontaneous fibronectin organization and stimulates growth factor signalling, enabling synergistic integrin and BMP‐2 receptor activation in mesenchymal stem cells. To translate this technology, plasma‐polymerized PEA is used on 2D and 3D substrates to enhance cell signalling in vitro, showing the complete healing of a critical‐sized bone injury in mice in vivo. Efficacy is demonstrated in a Münsterländer dog with a nonhealing humerus fracture, establishing the clinical translation of advanced ultralow‐dose growth factor treatment.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects ; volume:6 ; number:2 ; year:2019 ; extent:12
Advanced science ; 6, Heft 2 (2019) (gesamt 12)
- Creator
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Cheng, Zhe A.
Alba‐Perez, Andres
Gonzalez‐Garcia, Cristina
Donnelly, Hannah
Llopis‐Hernandez, Virginia
Jayawarna, Vineetha
Childs, Peter
Shields, David W.
Cantini, Marco
Ruiz‐Cantu, Laura
Reid, Andrew
Windmill, James F. C.
Addison, Elena S.
Corr, Sandra
Marshall, William G.
Dalby, Matthew J.
Salmeron-Sanchez, Manuel
- DOI
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10.1002/advs.201800361
- URN
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urn:nbn:de:101:1-2022071912435559351650
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:26 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Cheng, Zhe A.
- Alba‐Perez, Andres
- Gonzalez‐Garcia, Cristina
- Donnelly, Hannah
- Llopis‐Hernandez, Virginia
- Jayawarna, Vineetha
- Childs, Peter
- Shields, David W.
- Cantini, Marco
- Ruiz‐Cantu, Laura
- Reid, Andrew
- Windmill, James F. C.
- Addison, Elena S.
- Corr, Sandra
- Marshall, William G.
- Dalby, Matthew J.
- Salmeron-Sanchez, Manuel
Other Objects (12)
High Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019)
Synthesis and Characterization of Functional Thin Ultra-Low Density Coatings Inside Hollow Spheres
Suppressing Structural Relaxation in Nanoscale Antimony to Enable Ultralow‐Drift Phase‐Change Memory Applications
Subthreshold Swing of 59 mV decade −1 in Nanoscale Flexible Ultralow‐Voltage Organic Transistors
Mimicking Bone Extracellular Matrix: From BMP‐2‐Derived Sequences to Osteogenic‐Multifunctional Coatings
Amphiphilic Nanoscale Antifog Coatings: Improved Chemical Robustness by Continuous Assembly of Polymers
BMP
BMP
BMP.
Nanoscale Visualization of Elastic Inhomogeneities at TiN Coatings Using Ultrasonic Force Microscopy
Nanoscale pores introduced into paper via mesoporous silica coatings using sol–gel chemistry
Fabrication of a porous SiO2 thin film with an ultralow refractive index for anti-reflective coatings
High Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019)
Synthesis and Characterization of Functional Thin Ultra-Low Density Coatings Inside Hollow Spheres
Suppressing Structural Relaxation in Nanoscale Antimony to Enable Ultralow‐Drift Phase‐Change Memory Applications
Subthreshold Swing of 59 mV decade −1 in Nanoscale Flexible Ultralow‐Voltage Organic Transistors
Mimicking Bone Extracellular Matrix: From BMP‐2‐Derived Sequences to Osteogenic‐Multifunctional Coatings
Amphiphilic Nanoscale Antifog Coatings: Improved Chemical Robustness by Continuous Assembly of Polymers
BMP
BMP
BMP.
Nanoscale Visualization of Elastic Inhomogeneities at TiN Coatings Using Ultrasonic Force Microscopy
Nanoscale pores introduced into paper via mesoporous silica coatings using sol–gel chemistry
Fabrication of a porous SiO2 thin film with an ultralow refractive index for anti-reflective coatings
High Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019)
Synthesis and Characterization of Functional Thin Ultra-Low Density Coatings Inside Hollow Spheres
Suppressing Structural Relaxation in Nanoscale Antimony to Enable Ultralow‐Drift Phase‐Change Memory Applications
Subthreshold Swing of 59 mV decade −1 in Nanoscale Flexible Ultralow‐Voltage Organic Transistors
Mimicking Bone Extracellular Matrix: From BMP‐2‐Derived Sequences to Osteogenic‐Multifunctional Coatings
Amphiphilic Nanoscale Antifog Coatings: Improved Chemical Robustness by Continuous Assembly of Polymers
BMP
BMP
BMP.
Nanoscale Visualization of Elastic Inhomogeneities at TiN Coatings Using Ultrasonic Force Microscopy
Nanoscale pores introduced into paper via mesoporous silica coatings using sol–gel chemistry