The influence of glucocorticoids on neuronal survival and synaptic function
Abstract: Glucocorticoids, recognized as stress-related steroid hormones secreted from adrenal glands, have multiple roles in brain function. The concentration of glucocorticoids is regulated by the hypothalamic-pituitary-adrenal axis, and chronically elevated levels of glucocorticoids are putatively involved in the pathophysiology of mental disorders, such as depression. As corticosteroids are also widely used as medical drugs (e.g., for chronic lung disease in infants), the developmental influence of glucocorticoids on neuronal survival and synaptic plasticity is a critical concern. Although many reports suggest a biological effect of glucocorticoids on neuronal populations of the central nervous system (CNS), some reports suggest a possibility that glial responses (including regulation of neurotrophic factor expression) to glucocorticoids are different from that of neurons. In the present review, we show an overview of the current knowledge concerning the impact of glucocorticoids on behavior in animal models of depression, and on cell survival and function in the CNS.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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The influence of glucocorticoids on neuronal survival and synaptic function ; volume:3 ; number:6 ; year:2012 ; pages:495-504
Biomolecular concepts ; 3, Heft 6 (2012), 495-504
- Creator
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Numakawa, Tadahiro
Adachi, Naoki
Richards, Misty
Chiba, Shuichi
Kunugi, Hiroshi
- DOI
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10.1515/bmc-2012-0012
- URN
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urn:nbn:de:101:1-2409241609442.852977049328
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:21 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Numakawa, Tadahiro
- Adachi, Naoki
- Richards, Misty
- Chiba, Shuichi
- Kunugi, Hiroshi
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