PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid

Abstract: Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are linked in the onset and pathogenesis of numerous diseases. This has led to considerable interest in defining the mechanisms responsible for regulating mitochondria during ER stress. The PERK signaling arm of the unfolded protein response (UPR) has emerged as a prominent ER stress‐responsive signaling pathway that regulates diverse aspects of mitochondrial biology. Here, we show that PERK activity promotes adaptive remodeling of mitochondrial membrane phosphatidic acid (PA) to induce protective mitochondrial elongation during acute ER stress. We find that PERK activity is required for ER stress‐dependent increases in both cellular PA and YME1L‐dependent degradation of the intramitochondrial PA transporter PRELID1. These two processes lead to the accumulation of PA on the outer mitochondrial membrane where it can induce mitochondrial elongation by inhibiting mitochondrial fission. Our results establish a new role for PERK in the adaptive remodeling of mitochondrial phospholipids and demonstrate that PERK‐dependent PA regulation adapts organellar shape in response to ER stress.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid ; day:12 ; month:06 ; year:2023 ; extent:14 ; The EMBO journal / European Molecular Biology Organization ; (12.06.2023) (gesamt 14)

Contributors, Places and Time

• Creator: Perea, Valerie ; Cole, Christian ; Lebeau, Justine ; Dolina, Vivian ; Baron, Kelsey R. ; Madhavan, Aparajita ; Kelly, Jeffery W. ; Grotjahn, Danielle A. ; Wiseman, R. Luke

Further information

• DOI: 10.15252/embj.2023113908
• URN: urn:nbn:de:101:1-2023062315374242562292
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 11:02 AM CEST