Global quantitative proteomic analysis of aged mouse hippocampus
Abstract: Understanding the molecular changes associated with the aged brain forms the basis for developing potential strategies for slowing cognitive decline associated with normal aging. Focusing on the hippocampus, a critical brain region involved in learning and memory, we employed tandem mass tag methodology to investigate global proteomic changes that occur in advanced‐aged (20‐month) versus young (3‐month) C57BL/6 male mice. Our analysis revealed the upregulation of 236 proteins in the old hippocampal proteome, including those enriched within several age‐related processes, such as the adaptive immune response and molecular metabolic pathways, whereas downregulated proteins (88 in total) are mainly involved in axonogenesis and growth cone‐related processes. Categorizing proteins by cell‐type enrichment in the brain identified a general upregulation of proteins preferentially expressed in microglia, astrocytes, and oligodendrocytes. In contrast, proteins with neuron‐specific expression displayed an overall age‐related downregulation. By integrating our proteomic with our previously published transcriptomic data, we discovered a mild but significant positive correlation between mRNA and protein expression changes in the aged hippocampus. Therefore, this proteomic data is a valuable additional resource for further understanding age‐related molecular mechanisms.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Global quantitative proteomic analysis of aged mouse hippocampus ; day:19 ; month:12 ; year:2023 ; extent:6
Proteomics ; (19.12.2023) (gesamt 6)
- Urheber
-
Huang, He
van Waardenberg, Ashley J.
Graham, Mark E.
Anggono, Victor
Widagdo, Jocelyn
- DOI
-
10.1002/pmic.202300276
- URN
-
urn:nbn:de:101:1-2023122014063665467746
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:25 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Huang, He
- van Waardenberg, Ashley J.
- Graham, Mark E.
- Anggono, Victor
- Widagdo, Jocelyn
Ähnliche Objekte (12)
Special issue: CAR‐T cell therapy for hematological malignancies
Mesenchymal stem cells in rabbit meniscus and bone marrow exhibit a similar feature but a heterogeneous multi-differentiation potential: superiority of meniscus as a cell source for meniscus repair
An in vivo study of the best light emitting diode (LED) systems for cut chrysanthemums
The breakthrough and the future: CD20 chimeric antigen receptor T‐cell therapy for hematologic malignancies
How do commodity futures respond to macroeconomic news?
Geographic structure of Chinese dialects: a computational dialectometric approach
Global Structure-From-Motion Enhanced Neural Radiance Fields 3D Reconstruction
Enhancing A82846B production by artificial attB-assisted overexpression of orf10–orf11 genes in Kibdelosporangium aridum SIPI-3927
Difficult removal: a Swan-Ganz catheter coiled on the central venous catheter
Short-time AOIs-based representative scanpath identification and scanpath aggregation
Recent developments in biofeedback for neuromotor rehabilitation
Optimal estimation of cloud properties from thermal infrared observations with a combination of deep learning and radiative transfer simulation
Special issue: CAR‐T cell therapy for hematological malignancies
Mesenchymal stem cells in rabbit meniscus and bone marrow exhibit a similar feature but a heterogeneous multi-differentiation potential: superiority of meniscus as a cell source for meniscus repair
An in vivo study of the best light emitting diode (LED) systems for cut chrysanthemums
The breakthrough and the future: CD20 chimeric antigen receptor T‐cell therapy for hematologic malignancies
How do commodity futures respond to macroeconomic news?
Geographic structure of Chinese dialects: a computational dialectometric approach
Global Structure-From-Motion Enhanced Neural Radiance Fields 3D Reconstruction
Enhancing A82846B production by artificial attB-assisted overexpression of orf10–orf11 genes in Kibdelosporangium aridum SIPI-3927
Difficult removal: a Swan-Ganz catheter coiled on the central venous catheter
Short-time AOIs-based representative scanpath identification and scanpath aggregation
Recent developments in biofeedback for neuromotor rehabilitation
Optimal estimation of cloud properties from thermal infrared observations with a combination of deep learning and radiative transfer simulation
Special issue: CAR‐T cell therapy for hematological malignancies
Mesenchymal stem cells in rabbit meniscus and bone marrow exhibit a similar feature but a heterogeneous multi-differentiation potential: superiority of meniscus as a cell source for meniscus repair
An in vivo study of the best light emitting diode (LED) systems for cut chrysanthemums
The breakthrough and the future: CD20 chimeric antigen receptor T‐cell therapy for hematologic malignancies
How do commodity futures respond to macroeconomic news?
Geographic structure of Chinese dialects: a computational dialectometric approach
Global Structure-From-Motion Enhanced Neural Radiance Fields 3D Reconstruction
Enhancing A82846B production by artificial attB-assisted overexpression of orf10–orf11 genes in Kibdelosporangium aridum SIPI-3927
Difficult removal: a Swan-Ganz catheter coiled on the central venous catheter
Short-time AOIs-based representative scanpath identification and scanpath aggregation
Recent developments in biofeedback for neuromotor rehabilitation