β‐Cyclodextrin and folic acid host–guest interaction binding parameters determined by Taylor dispersion analysis and affinity capillary electrophoresis
Abstract: The thermodynamic properties of molecular recognition in host–guest inclusion complexes can be studied by Taylor dispersion analysis (TDA). Host–guest inclusion complexes have modest size, and it is possible to get convergent results fast, achieving greater certainty for the obtained thermodynamic properties. Cyclodextrins (CDs) and their derivatives can be used as drug carriers that can boost stability, solubility, and bioavailability of physiologically active substances. A simple and effective approach for assessing the binding properties of CD complexes that are critical in the early stages of drug and formulation development is needed to fully understand the process of CD and guest molecules’ complex formation. In this work, TDA was successfully used to rapidly determine interaction parameters, including binding constant and stoichiometry, between β‐CD and folic acid (FA) along with the diffusivities of the free FA and its complex with β‐CD. Additionally, the FA diffusion coefficient obtained by TDA was compared to the results previously obtained by nuclear magnetic resonance. Affinity capillary electrophoresis (ACE) was also used to compare the binding constants obtained by different methods. The results showed that the binding constants obtained by ACE were somewhat lower than those obtained by the two TDA procedures.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
β‐Cyclodextrin and folic acid host–guest interaction binding parameters determined by Taylor dispersion analysis and affinity capillary electrophoresis ; day:29 ; month:03 ; year:2023 ; extent:10
Electrophoresis ; (29.03.2023) (gesamt 10)
- Urheber
-
Dai, Yuanli
Sun, Chang
Yang, Yunhe
Wang, Shuanghao
Li, Huihui
Chen, David Da Yong
- DOI
-
10.1002/elps.202200279
- URN
-
urn:nbn:de:101:1-2023033015011551292187
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 11:00 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Dai, Yuanli
- Sun, Chang
- Yang, Yunhe
- Wang, Shuanghao
- Li, Huihui
- Chen, David Da Yong
Ähnliche Objekte (12)
Fluorescence quenching in β-cyclodextrin vesicles: membrane confinement and host-guest interactions
Chiral resolution of cationic piperazine derivatives by capillary electrophoresis using sulfated β‐cyclodextrin
Space filling of β-cyclodextrin and β-cyclodextrin derivatives by volatile hydrophobic guests
Lysosomal Targeting of β‐Cyclodextrin
![Konjugate bioaktiver Peptide mit β-Cyclodextrin [Beta-Cyclodextrin]](/assets/placeholder/searchResultMediaNoDigitisedMedia.png)
Konjugate bioaktiver Peptide mit β-Cyclodextrin [Beta-Cyclodextrin]
Regioselektive Funktionalisierung von Stärke und β-Cyclodextrin [Beta-Cyclodextrin]
Strukturelle Eigenschaften und chemische Modifizierungen von β-Cyclodextrin [Beta-Cyclodextrin]
Synthese von Rezeptormolekülen auf Basis von β-Cyclodextrin [Beta-Cyclodextrin]
SYNTHESIS OF NEW FLUORESCENT β-CYCLODEXTRIN SENSOR
Biofilm-based biocatalysis for β-cyclodextrin production by the surface-display of β-cyclodextrin glycosyltransferase in Bacillus subtilis
Chiral separation of cathinone derivatives using β‐cyclodextrin‐assisted capillary electrophoresis–Comparison of four different β‐cyclodextrin derivatives used as chiral selectors
Host-guest complexes of imazalil with cucurbit[8]uril and β-cyclodextrin and their effect on plant pathogenic fungi
Fluorescence quenching in β-cyclodextrin vesicles: membrane confinement and host-guest interactions
Chiral resolution of cationic piperazine derivatives by capillary electrophoresis using sulfated β‐cyclodextrin
Space filling of β-cyclodextrin and β-cyclodextrin derivatives by volatile hydrophobic guests
Lysosomal Targeting of β‐Cyclodextrin
Konjugate bioaktiver Peptide mit β-Cyclodextrin [Beta-Cyclodextrin]
Regioselektive Funktionalisierung von Stärke und β-Cyclodextrin [Beta-Cyclodextrin]
Strukturelle Eigenschaften und chemische Modifizierungen von β-Cyclodextrin [Beta-Cyclodextrin]
Synthese von Rezeptormolekülen auf Basis von β-Cyclodextrin [Beta-Cyclodextrin]
SYNTHESIS OF NEW FLUORESCENT β-CYCLODEXTRIN SENSOR
Biofilm-based biocatalysis for β-cyclodextrin production by the surface-display of β-cyclodextrin glycosyltransferase in Bacillus subtilis
Chiral separation of cathinone derivatives using β‐cyclodextrin‐assisted capillary electrophoresis–Comparison of four different β‐cyclodextrin derivatives used as chiral selectors
Host-guest complexes of imazalil with cucurbit[8]uril and β-cyclodextrin and their effect on plant pathogenic fungi
Fluorescence quenching in β-cyclodextrin vesicles: membrane confinement and host-guest interactions
Chiral resolution of cationic piperazine derivatives by capillary electrophoresis using sulfated β‐cyclodextrin
Space filling of β-cyclodextrin and β-cyclodextrin derivatives by volatile hydrophobic guests
Lysosomal Targeting of β‐Cyclodextrin
Konjugate bioaktiver Peptide mit β-Cyclodextrin [Beta-Cyclodextrin]
Regioselektive Funktionalisierung von Stärke und β-Cyclodextrin [Beta-Cyclodextrin]
Strukturelle Eigenschaften und chemische Modifizierungen von β-Cyclodextrin [Beta-Cyclodextrin]
Synthese von Rezeptormolekülen auf Basis von β-Cyclodextrin [Beta-Cyclodextrin]
SYNTHESIS OF NEW FLUORESCENT β-CYCLODEXTRIN SENSOR
Biofilm-based biocatalysis for β-cyclodextrin production by the surface-display of β-cyclodextrin glycosyltransferase in Bacillus subtilis
Chiral separation of cathinone derivatives using β‐cyclodextrin‐assisted capillary electrophoresis–Comparison of four different β‐cyclodextrin derivatives used as chiral selectors